<p>Preparation of a nanostructured surface that is effective in hydroxyapatite adhesion and corrosion resistance, using an easy and efficient microwave plasma technique at three voltages (50, 100, 150 V). The technique demonstrated its effectiveness in enhancing structural properties to improve hydroxyapatite (HA) implantation in bone formation after immersing the samples in simulated body fluid (SBF) for 14 days. Optical Emission Spectroscopy (OES) shows the strongest electronic transitions (AI, AII) associated with zinc oxide. The X-ray diffraction (XRD) patterns before the deposition of (HA) show a higher diffraction peak between (40 and 45°), indicating the formation of a hexagonal close-packed structure of Zn. After deposition, zinc oxide and phosphate and calcium compounds appeared. Field Emission Scanning Electron Microscope (FE-SEM) images showed the effect of increasing voltage on the change in surface topography before and after deposition. Raman analysis showed a characteristic peak for wurtzite-type zinc oxide at E₂, and lattice vibrations were confirmed by the (TO + LO) peak. Fourier Transform Infrared Spectroscopy (FTIR) clearly showed the deposition of (HA) on the zinc surface through the vibrational bonds that appeared. Energy dispersive spectroscopy (EDS) confirmed the elemental percentages for (HA) after deposition The surface transformed into a hydrophilic state after plasma exposure, with a contact angle of up to 23.69°, confirming increased surface activity. As for the corrosion current at 50 V, it recorded (0.16 µA/cm²) and then decreased at 150 V (0.11 µA/cm²) after immersion in hydroxyapatite solution. In contrast, the polarization resistance value increased at 50 V from (0.156 kΩ•cm²) to about 0.245 kΩ•cm² for the sample at 150 V. This indicates an improvement in corrosion resistance with increasing voltage and the formation of a hydroxyapatite layer on the zinc surface.</p> Graphical abstract <p></p>