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<p>This study describes a new point-of-care (POC) diagnostic method that uses a rectangular pocket-based dopingless TFET (RP-DLTFET) with a dual source cavity structure to detect cancerous liver cell lines. The drain current sensitivity increases by combining Si<sub>0.6</sub>Ge<sub>0.4</sub> as the source pocket material with HfO<sub>2</sub> as the gate dielectric. The suggested biosensor is outfitted with nanocavities by trenching the gate oxide layer, where the liver sample acquired by needle biopsy was immobilized. The sensor’s I<sub>ON</sub>/I<sub>OFF</sub> current ratio and drain current are considered for estimating different sensitivities and serve as the basis for the detection. Here, the variation in the dielectric constant of the specimen at 900&#xa0;MHz has been taken into account. Several device characteristics have been investigated, including parameters such as temperature, percentage of cells present in the specimen, interface trap charges, and the variation in oxide material. All the work, including analyzing the various percentages of healthy and cancerous cells in a given specimen, has been completed in a simulation environment. The suggested approach, which can be used as a POC diagnostic to determine whether the specimen liver cell line is cancerous, can be considered a unique technique. The proposed RP-DLTFET biosensor displays a higher value of <InlineEquation ID="IEq1"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="542_2025_5959_Article_IEq1.gif" Format="GIF" Height="19" Rendition="HTML" Resolution="72" Type="Linedraw" Width="30" /> </InlineMediaObject> <EquationSource Format="TEX">\(\:{\text{S}}_{{\text{I}}_{\text{O}\text{N}}}\)</EquationSource> </InlineEquation> of 1.97 × 10<sup>12</sup> and <InlineEquation ID="IEq2"> <InlineMediaObject> <ImageObject Color="BlackWhite" FileRef="542_2025_5959_Article_IEq2.gif" Format="GIF" Height="20" Rendition="HTML" Resolution="72" Type="Linedraw" Width="61" /> </InlineMediaObject> <EquationSource Format="TEX">\(\:{\text{S}}_{{\text{I}}_{\text{O}\text{N}}/{\text{I}}_{\text{O}\text{F}\text{F}}}\:\)</EquationSource> </InlineEquation>of 3.82 × 10<sup>9</sup> for cancerous cells at room temperature.</p>

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Design and sensitivity investigation of a rectangular pocket based dopingless TFET biosensor for liver cancer detection

  • 期刊论文

  • 发表日期：

    2025年9月25日

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  • Shwetapadma Panda,
  • Sidhartha Dash

摘要

This study describes a new point-of-care (POC) diagnostic method that uses a rectangular pocket-based dopingless TFET (RP-DLTFET) with a dual source cavity structure to detect cancerous liver cell lines. The drain current sensitivity increases by combining Si0.6Ge0.4 as the source pocket material with HfO2 as the gate dielectric. The suggested biosensor is outfitted with nanocavities by trenching the gate oxide layer, where the liver sample acquired by needle biopsy was immobilized. The sensor’s ION/IOFF current ratio and drain current are considered for estimating different sensitivities and serve as the basis for the detection. Here, the variation in the dielectric constant of the specimen at 900 MHz has been taken into account. Several device characteristics have been investigated, including parameters such as temperature, percentage of cells present in the specimen, interface trap charges, and the variation in oxide material. All the work, including analyzing the various percentages of healthy and cancerous cells in a given specimen, has been completed in a simulation environment. The suggested approach, which can be used as a POC diagnostic to determine whether the specimen liver cell line is cancerous, can be considered a unique technique. The proposed RP-DLTFET biosensor displays a higher value of \(\:{\text{S}}_{{\text{I}}_{\text{O}\text{N}}}\) of 1.97 × 1012 and \(\:{\text{S}}_{{\text{I}}_{\text{O}\text{N}}/{\text{I}}_{\text{O}\text{F}\text{F}}}\:\) of 3.82 × 109 for cancerous cells at room temperature.