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<p>Paper-based microfluidic devices offer a low-cost, portable platform for diagnostics, yet user-controlled fluidic switching for multi-step assays remains challenging. We present a scalable method to fabricate triggerable fluidic gates in paper substrates using wax printing. Hydrophobic wax barriers (0.5–1&#xa0;mm thick) block flow (“OFF” state) until locally heated above their melting point (~ 100&#xa0;°C, “ON” state), enabling on-demand fluid release at ~$0.1/device. Using a Xerox ColorQube 8580 and biocompatible wax, this approach requires no solvents or complex equipment. We demonstrate its efficacy via global (hot plate, 5&#xa0;s trigger) and localized (wax pen, 3&#xa0;s; c.w. laser, 2&#xa0;s) heating, validated by microscopy and assays for nitrite detection (LOD: 0.1 mM) and C-reactive protein (CRP) sandwich ELISA (LOD: 0.01&#xa0;µg/mL). This contamination-free strategy enhances paper-based sensors for point-of-care diagnostics.</p>

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Triggerable fluidic gates in paper-based microfluidic devices using printed wax barriers

  • 期刊论文

  • 发表日期：

    2025年9月5日

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  • Peijun He,
  • Haiqin Tan,
  • Lin Chen,
  • Bo Yu,
  • Zhinan Xu

摘要

Paper-based microfluidic devices offer a low-cost, portable platform for diagnostics, yet user-controlled fluidic switching for multi-step assays remains challenging. We present a scalable method to fabricate triggerable fluidic gates in paper substrates using wax printing. Hydrophobic wax barriers (0.5–1 mm thick) block flow (“OFF” state) until locally heated above their melting point (~ 100 °C, “ON” state), enabling on-demand fluid release at ~$0.1/device. Using a Xerox ColorQube 8580 and biocompatible wax, this approach requires no solvents or complex equipment. We demonstrate its efficacy via global (hot plate, 5 s trigger) and localized (wax pen, 3 s; c.w. laser, 2 s) heating, validated by microscopy and assays for nitrite detection (LOD: 0.1 mM) and C-reactive protein (CRP) sandwich ELISA (LOD: 0.01 µg/mL). This contamination-free strategy enhances paper-based sensors for point-of-care diagnostics.