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<p>Transdermal medication using hollow microneedle arrays (HMAs), provides a painless and hygienic alternative drug delivery system for hypodermic (ordinary) injections. The delivery of different therapeutic medicines throughout the body has become challenging due to the strong barrier, like the stratum corneum. Several limitations like the slow rate of drug delivery through solid, coated, and dissolving microneedles may in Transdermal drug delivery system (TDD) can be resolved using hollow microneedles (HMNs) which enables increased drug delivery rate as per the requirement. Thus, an investigation has been carried out to fabricate biocompatible resin-based HMAs with specific sizes using stereolithography (SLA) Form 3B (Formlabs Inc.) 3D printer. This 3D printed HMAs integrated with a syringe connector shows a huge potential to deliver required medicines quickly and painlessly. In this study, an extensive research work has been carried out to develop a small HMAs with a hole inner diameter of 189–210&#xa0;μm with a height of 1.5&#xa0;mm for gene delivery applications. Here, a DMA 8000 was employed for mechanical strength test of HMN arrays which is useful for drug delivery. The electrophoresis technique was utilized to assess drug/gene delivery capability and Wistar rats were used for skin penetration studies respectively.</p>

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Fabrication of 3D printed hollow microneedle arrays for gene delivery applications

  • 期刊论文

  • 发表日期：

    2025年8月28日

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  • Pramod Kumar,
  • Rajeev Dhar Divedi,
  • Rusham Das,
  • Preshita Bhalerao,
  • Tarun Kumar Bhatt,
  • Milan Sasmal

摘要

Transdermal medication using hollow microneedle arrays (HMAs), provides a painless and hygienic alternative drug delivery system for hypodermic (ordinary) injections. The delivery of different therapeutic medicines throughout the body has become challenging due to the strong barrier, like the stratum corneum. Several limitations like the slow rate of drug delivery through solid, coated, and dissolving microneedles may in Transdermal drug delivery system (TDD) can be resolved using hollow microneedles (HMNs) which enables increased drug delivery rate as per the requirement. Thus, an investigation has been carried out to fabricate biocompatible resin-based HMAs with specific sizes using stereolithography (SLA) Form 3B (Formlabs Inc.) 3D printer. This 3D printed HMAs integrated with a syringe connector shows a huge potential to deliver required medicines quickly and painlessly. In this study, an extensive research work has been carried out to develop a small HMAs with a hole inner diameter of 189–210 μm with a height of 1.5 mm for gene delivery applications. Here, a DMA 8000 was employed for mechanical strength test of HMN arrays which is useful for drug delivery. The electrophoresis technique was utilized to assess drug/gene delivery capability and Wistar rats were used for skin penetration studies respectively.