Scholarlink

<p>Apoptosis is a cell-death process, focused at ensuring healthy life flow in both vertebrates and invertebrates. Apoptosis is induced by the majority anticancer drugs, chemotherapy and radiation, making it an area of intense research. In the present work, p53 protein led-apoptosis in <i>Drosophila Melanogaster</i> is studied comprehensively by mathematical modeling and designing the cytomorphic system of the process. For predicting intracellular protein-protein interactions under stress conditions, Ordinary Differential Equations (ODE) are formulated using Law of mass action. The system model is designed for the entire biological process using Michaelis-Menten kinetics for studying the characteristics of the pathway. The system model is mapped into electronics domain using MOS-based low-power, low noise differential amplifier. Existing technical computing tool, MATLAB R2014a and electronic circuit software Taiwan Semiconductor Manufacturing Company (TSMC) 180 nm CMOS process are used for hierarchical modeling, design, and analysis of proposed cell-inspired schematics. Simulated responses of each participating protein resembles their biological nature and verifies their role in the pathway. The outcomes of the model are verified with the obtained results of bio-simulator COPASI 4.25 and cell-cultured data.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

A bio-inspired analog electronics circuit design for cell-death process of invertebrates

  • 期刊论文

  • 发表日期：

    2025年6月4日

查看全文
  • Trisha Patra,
  • Soma Barman Mandal

摘要

Apoptosis is a cell-death process, focused at ensuring healthy life flow in both vertebrates and invertebrates. Apoptosis is induced by the majority anticancer drugs, chemotherapy and radiation, making it an area of intense research. In the present work, p53 protein led-apoptosis in Drosophila Melanogaster is studied comprehensively by mathematical modeling and designing the cytomorphic system of the process. For predicting intracellular protein-protein interactions under stress conditions, Ordinary Differential Equations (ODE) are formulated using Law of mass action. The system model is designed for the entire biological process using Michaelis-Menten kinetics for studying the characteristics of the pathway. The system model is mapped into electronics domain using MOS-based low-power, low noise differential amplifier. Existing technical computing tool, MATLAB R2014a and electronic circuit software Taiwan Semiconductor Manufacturing Company (TSMC) 180 nm CMOS process are used for hierarchical modeling, design, and analysis of proposed cell-inspired schematics. Simulated responses of each participating protein resembles their biological nature and verifies their role in the pathway. The outcomes of the model are verified with the obtained results of bio-simulator COPASI 4.25 and cell-cultured data.