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<p>Nowadays, microfluidic paper-based analytical devices (µPADs) have become popular due to paper’s capability to transport fluids passively through capillary action. They offer a user-friendly alternative to traditional analytical tools. This study presents a novel, simple, and rapid technique for creating µPADs with customized patterns using a fused deposition modelling 3D printer, aiming to develop an efficient and cost-effective fabrication method. Various parameters affecting the quality of µPADs fabrication were analyzed and optimized. In this method, the produced µPADs consist of paper adhered to a rigid substrate made from printed polylactic acid filament. The wetted times of the fabricated µPADs were compared to those made using the cutting method, which was reduced by an average of 2.2 times, to evaluate capillary fluid flow and changes in the paper fiber network. It was found that this method reduces fluid consumption by one-third compared to the paper-cutting method. To asess the performance of the fabricated chip, pH and nitrite tests were successfully performed. Regression coefficients for the pH and nitrite colorimetric tests were R2 = 0.965 and 0.9876, respectively, indicating a strong linear fit of the correlation curves. The colorimetric analysis of the pH test indicates that the coefficient of variation was 10% at pH 7 and 6% at pH 10. Good reproducibility obtained from the results ensures that the fabricated µPADs with the reported technique provide a robust platform for performing chemical and point-of-care tests.</p>

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A novel approach to rapid fabrication of robust paper-based microfluidic devices using FDM 3D printing

  • 期刊论文

  • 发表日期：

    2025年4月28日

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  • Mehdi Mehri,
  • Ali Abouei Mehrizi,
  • Mohammad Ajoudanian,
  • Sogol Fathi,
  • Saeed Mohammadi,
  • Kazem Sharifi

摘要

Nowadays, microfluidic paper-based analytical devices (µPADs) have become popular due to paper’s capability to transport fluids passively through capillary action. They offer a user-friendly alternative to traditional analytical tools. This study presents a novel, simple, and rapid technique for creating µPADs with customized patterns using a fused deposition modelling 3D printer, aiming to develop an efficient and cost-effective fabrication method. Various parameters affecting the quality of µPADs fabrication were analyzed and optimized. In this method, the produced µPADs consist of paper adhered to a rigid substrate made from printed polylactic acid filament. The wetted times of the fabricated µPADs were compared to those made using the cutting method, which was reduced by an average of 2.2 times, to evaluate capillary fluid flow and changes in the paper fiber network. It was found that this method reduces fluid consumption by one-third compared to the paper-cutting method. To asess the performance of the fabricated chip, pH and nitrite tests were successfully performed. Regression coefficients for the pH and nitrite colorimetric tests were R2 = 0.965 and 0.9876, respectively, indicating a strong linear fit of the correlation curves. The colorimetric analysis of the pH test indicates that the coefficient of variation was 10% at pH 7 and 6% at pH 10. Good reproducibility obtained from the results ensures that the fabricated µPADs with the reported technique provide a robust platform for performing chemical and point-of-care tests.