Scholarlink

<p>This prespecified secondary analysis of a randomized controlled trial investigated event-related dynamics of the Nociception Level (NOL) index during tracheal intubation and initiation of pneumoperitoneum in patients undergoing robot-assisted laparoscopic radical prostatectomy. Continuous NOL values recorded every 5&#xa0;s were analyzed within 5-min windows before and after each event using segmented regression models within a comparative interrupted time series (ITS) framework incorporating a contemporaneous control group. Forty-nine patients were included (NOL-guided, <i>n</i> = 25; control, <i>n</i> = 24). At intubation, the NOL-guided group showed a lower pre-event baseline (12.2 vs 19.2; group difference − 6.97, <i>p</i> = 0.003) and a reduced post-event peak (32.9 vs 44.1; − 11.2, <i>p</i> = 0.034), whereas immediate level changes did not differ (<i>p</i> = 0.82). Similar findings were observed at pneumoperitoneum, with lower baseline (8.09 vs 12.0; − 3.93, <i>p</i> = 0.024) and peak NOL values (12.9 vs 23.6; − 10.8, <i>p</i> = 0.013) but no difference in immediate level change (<i>p</i> = 0.47). By integrating a prespecified secondary analysis within a comparative ITS framework, this study offers a time-resolved perspective on intraoperative NOL dynamics beyond conventional event-based analyses.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Comparative interrupted time series analysis of Nociception Level index during tracheal intubation and pneumoperitoneum in robot-assisted laparoscopic radical prostatectomy: a sub-analysis of the NOLDOR study

  • 期刊论文

  • 发表日期：

    2026年4月4日

查看全文
  • Nobuhiro Tanaka,
  • Naoki Ozu,
  • Yuma Kadoya,
  • Mitsuru Ida,
  • Takanori Suzuka,
  • Takayuki Yamanaka,
  • Masahiko Kawaguchi

摘要

This prespecified secondary analysis of a randomized controlled trial investigated event-related dynamics of the Nociception Level (NOL) index during tracheal intubation and initiation of pneumoperitoneum in patients undergoing robot-assisted laparoscopic radical prostatectomy. Continuous NOL values recorded every 5 s were analyzed within 5-min windows before and after each event using segmented regression models within a comparative interrupted time series (ITS) framework incorporating a contemporaneous control group. Forty-nine patients were included (NOL-guided, n = 25; control, n = 24). At intubation, the NOL-guided group showed a lower pre-event baseline (12.2 vs 19.2; group difference − 6.97, p = 0.003) and a reduced post-event peak (32.9 vs 44.1; − 11.2, p = 0.034), whereas immediate level changes did not differ (p = 0.82). Similar findings were observed at pneumoperitoneum, with lower baseline (8.09 vs 12.0; − 3.93, p = 0.024) and peak NOL values (12.9 vs 23.6; − 10.8, p = 0.013) but no difference in immediate level change (p = 0.47). By integrating a prespecified secondary analysis within a comparative ITS framework, this study offers a time-resolved perspective on intraoperative NOL dynamics beyond conventional event-based analyses.