<p>Breast cancer recurrence remains a significant challenge in oncology, impacting patient prognosis and treatment strategies. Early and accurate prediction of recurrence can enhance clinical decision-making and improve patient outcomes. In this study, we propose a novel Optimized Prediction Algorithm (OPA) that integrates attention mechanisms, active learning, and eXplainable Artificial Intelligence (XAI) to predict breast cancer recurrence. The proposed OPA algorithm was trained and validated on a comprehensive dataset of breast cancer patients, achieving 94.5% accuracy, 92.7% sensitivity, and 95.8% specificity, outperforming existing models. Furthermore, the incorporation of XAI techniques ensures model interpretability by providing transparent insights into key predictive factors, thereby increasing clinical trust and applicability. The OPA algorithm holds great potential for assisting oncologists in identifying high-risk patients and enabling timely intervention for improved patient care.</p>

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An explainable AI-powered algorithm for predicting breast cancer recurrence using attention mechanisms and active learning

  • Fatma M. Talaat,
  • Mohamed Abdelkhalek,
  • Saleh Saleh Elbalka,
  • Ahmed Abdallah

摘要

Breast cancer recurrence remains a significant challenge in oncology, impacting patient prognosis and treatment strategies. Early and accurate prediction of recurrence can enhance clinical decision-making and improve patient outcomes. In this study, we propose a novel Optimized Prediction Algorithm (OPA) that integrates attention mechanisms, active learning, and eXplainable Artificial Intelligence (XAI) to predict breast cancer recurrence. The proposed OPA algorithm was trained and validated on a comprehensive dataset of breast cancer patients, achieving 94.5% accuracy, 92.7% sensitivity, and 95.8% specificity, outperforming existing models. Furthermore, the incorporation of XAI techniques ensures model interpretability by providing transparent insights into key predictive factors, thereby increasing clinical trust and applicability. The OPA algorithm holds great potential for assisting oncologists in identifying high-risk patients and enabling timely intervention for improved patient care.