Purpose <p>Sleep disorders are highly prevalent among lung cancer patients and seriously affect their quality of life and mental health. This systematic review and meta-analysis aimed to assess the effects of non-pharmacological interventions on sleep quality, quality of life, and anxiety in lung cancer patients.</p> Methods <p>PubMed, Web of Science, Cochrane Library, CINAHL, Embase, CNKI, Wanfang Data, and VIP databases for studies published between 2015 and February 2025. The primary outcome was sleep quality, with quality of life and anxiety levels as secondary outcomes. We assessed the risk of bias using the Cochrane tool and synthesized data using meta-analysis.</p> Results <p>Twenty-four studies involving 2604 patients were included. Non-pharmacological interventions were compared with usual care, placebo, or standard oncology care. After excluding studies with inappropriate content and methods, 20 studies evaluated sleep quality, and 12 studies evaluated quality of life and anxiety levels, respectively. The quality of the evidence was low to moderate; the promotion results should be interpreted with caution, but they may have a positive effect on the sleep quality, quality of life, and anxiety levels of lung cancer patients.</p> Conclusions <p>Diverse non-pharmacological interventions can improve sleep quality, quality of life, and anxiety in lung cancer patients. However, high-quality, rigorously designed randomized controlled trials are still needed to confirm these findings. Future research should focus on personalized interventions tailored to lung cancer patients’ characteristics and integrate digital health interventions to better support clinical decision-making.</p>