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Purpose <p>Sarcopenia is a prevalent musculoskeletal complication after pediatric cancer, and its association with health-related quality of life (HRQoL) remains unknown. This study aimed to investigate health-related quality of life (HRQoL) differences according to sarcopenia status in young pediatric cancer survivors, and determined if these differences were distinct by sex.</p> Methods <p>This cross-sectional study included 116 pediatric cancer survivors (12.1 ± 3.3&#xa0;years old). Muscle strength was evaluated by handgrip strength test, while appendicular lean mass index (ALMI, kg/m<sup>2</sup>) was estimated via dual‑energy X‑ray absorptiometry. “Sarcopenia probable” was defined when muscle strength was ≤ decile 2 and ALMI Z-score was &gt; -1.5 standard deviation (SD). “Sarcopenia confirmed” was defined when muscle strength was ≤ decile 2 and ALMI Z-score ≤ -1.5 SD. HRQoL was assessed using the Spanish version of the PedsQL 4.0 Generic Core Scales, and compared with age-specific reference values of healthy young population to calculate Z-scores.</p> Results <p>Only female survivors without sarcopenia had significantly better total HRQoL (-0.3 [95% CI: -0.8 to 0.2] vs. 1.5 [95% CI: -2.1 to -0.8]), physical HRQoL (-0.3 [95% CI: -0.8 to 0.2] vs. -1.6 [95% CI: -2.3 to -0.9]), psychosocial HRQoL (-0.2 [95% CI: -0.7 to 0.3] vs. -1.2 [95% CI: -1.8 to -0.6]) and school HRQoL (-0.1 [95% CI: -0.6 to 0.4] vs. -1.3 [95% CI: -2.0 to -0.7]) than female survivors with sarcopenia confirmed.</p> Conclusion <p>Most HRQoL domains are similar across sarcopenia status in young pediatric cancer survivors. However, female survivors without sarcopenia seem to have better HRQoL Z-score than those with sarcopenia.</p>

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Health-related quality of life in young pediatric cancer survivors: The role of sarcopenia

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月15日

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  • Andres Marmol-Perez,
  • Esther Ubago-Guisado,
  • Cristina Cadenas-Sanchez,
  • Andrea Rodriguez-Solana,
  • Francisco J. Llorente-Cantarero,
  • Juan Francisco Pascual-Gázquez,
  • Daniel Moreira-Gonçalves,
  • Jorge Mota,
  • Kirsten K. Ness,
  • Jonatan R. Ruiz,
  • Luis Gracia-Marco

摘要

Purpose

Sarcopenia is a prevalent musculoskeletal complication after pediatric cancer, and its association with health-related quality of life (HRQoL) remains unknown. This study aimed to investigate health-related quality of life (HRQoL) differences according to sarcopenia status in young pediatric cancer survivors, and determined if these differences were distinct by sex.

Methods

This cross-sectional study included 116 pediatric cancer survivors (12.1 ± 3.3 years old). Muscle strength was evaluated by handgrip strength test, while appendicular lean mass index (ALMI, kg/m2) was estimated via dual‑energy X‑ray absorptiometry. “Sarcopenia probable” was defined when muscle strength was ≤ decile 2 and ALMI Z-score was > -1.5 standard deviation (SD). “Sarcopenia confirmed” was defined when muscle strength was ≤ decile 2 and ALMI Z-score ≤ -1.5 SD. HRQoL was assessed using the Spanish version of the PedsQL 4.0 Generic Core Scales, and compared with age-specific reference values of healthy young population to calculate Z-scores.

Results

Only female survivors without sarcopenia had significantly better total HRQoL (-0.3 [95% CI: -0.8 to 0.2] vs. 1.5 [95% CI: -2.1 to -0.8]), physical HRQoL (-0.3 [95% CI: -0.8 to 0.2] vs. -1.6 [95% CI: -2.3 to -0.9]), psychosocial HRQoL (-0.2 [95% CI: -0.7 to 0.3] vs. -1.2 [95% CI: -1.8 to -0.6]) and school HRQoL (-0.1 [95% CI: -0.6 to 0.4] vs. -1.3 [95% CI: -2.0 to -0.7]) than female survivors with sarcopenia confirmed.

Conclusion

Most HRQoL domains are similar across sarcopenia status in young pediatric cancer survivors. However, female survivors without sarcopenia seem to have better HRQoL Z-score than those with sarcopenia.