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Purpose <p>Our study aimed to design patient-centered interventions and test their feasibility, acceptability, and effectiveness in improving oral endocrine therapy (OET) adherence in underserved Black women.</p> Methods <p>This prospective study included adult, Black women on OET for either the prevention or treatment of breast cancer (BC) at Harris Health in Houston, TX, USA. The first intervention was a motivational interviewing (MI)-based telephone intervention consisting of six monthly calls. The second intervention was a one-time viewing of a theater-based educational video. OET adherence 6&#xa0;months before and during the MI intervention was measured using the proportion of days covered (PDC) and compared using a paired <i>t</i>-test. Participants also completed a survey at the end of both interventions to determine their acceptability. The survey responses were summarized descriptively.</p> Results <p>The majority of participants in MI (<i>n</i> = 20) and video (<i>n</i> = 25) interventions were satisfied with the intervention they received. During MI, the most common barriers identified were adverse drug reactions (hot flashes and muscle/joint pain) and forgetfulness. Three major cultural themes arose in our qualitative analysis: religion/spirituality, family, and trust in healthcare providers. Sixty-five percent of patients showed improved PDC during the intervention, while 24% of individuals who did not complete all 6 MI phone calls did not show improved PDC. There was no significant difference in OET adherence during the MI intervention.</p> Conclusion <p>A 6-month telephonic MI intervention and a one-time educational video were each feasible and acceptable approaches for promoting OET adherence in underserved Black women for prevention or treatment of BC.</p>

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Interventions to improve adherence to oral endocrine therapy for prevention or treatment of breast cancer in Black women of low socioeconomic status

  • 期刊论文

  • 发表日期：

    2025年12月11日

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  • Camille Johnson Powell,
  • Ann Adigwe,
  • Nicole Ekezie,
  • Bilqees Fatima,
  • Zahra Majd,
  • Reece Collins,
  • Keith Houk,
  • Tejal Patel,
  • Hilary Ma,
  • Rob Shimko,
  • Onyebuchi Ononogbu,
  • Susan Abughosh,
  • Meghana V. Trivedi

摘要

Purpose

Our study aimed to design patient-centered interventions and test their feasibility, acceptability, and effectiveness in improving oral endocrine therapy (OET) adherence in underserved Black women.

Methods

This prospective study included adult, Black women on OET for either the prevention or treatment of breast cancer (BC) at Harris Health in Houston, TX, USA. The first intervention was a motivational interviewing (MI)-based telephone intervention consisting of six monthly calls. The second intervention was a one-time viewing of a theater-based educational video. OET adherence 6 months before and during the MI intervention was measured using the proportion of days covered (PDC) and compared using a paired t-test. Participants also completed a survey at the end of both interventions to determine their acceptability. The survey responses were summarized descriptively.

Results

The majority of participants in MI (n = 20) and video (n = 25) interventions were satisfied with the intervention they received. During MI, the most common barriers identified were adverse drug reactions (hot flashes and muscle/joint pain) and forgetfulness. Three major cultural themes arose in our qualitative analysis: religion/spirituality, family, and trust in healthcare providers. Sixty-five percent of patients showed improved PDC during the intervention, while 24% of individuals who did not complete all 6 MI phone calls did not show improved PDC. There was no significant difference in OET adherence during the MI intervention.

Conclusion

A 6-month telephonic MI intervention and a one-time educational video were each feasible and acceptable approaches for promoting OET adherence in underserved Black women for prevention or treatment of BC.