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Background <p>Despite being among the most common cancer treatment-related side effects, taste disorders have received limited study, and their management remains challenging. Recent data have associated dysgeusia with decreased quality of life and increased mortality. We discuss here the state of the science on this topic and address clinical concerns and understudied therapeutics, with the aim of stressing the importance of this side effect and the need for effective treatment.</p> Methods <p>We selected extant articles covering cancer therapy-associated dysgeusia in English language peer-reviewed literature from PubMed, Medline, Cochrane Library, and Scopus databases. We identified 368 articles, of which 92 were reviewed in detail. The relevant publications have described heterogeneous populations and a multitude of clinical characteristics. The mechanisms of altered taste perception in cancer populations have not been completely elucidated, which in turn has impaired the development of potential interventions, including prevention and management.</p> Conclusion <p>Dysgeusia in cancer patients may be more relevant to treatment success and quality of life than previously accepted. Unfortunately, this topic has not been adequately addressed and requires further study.</p>

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Taste disorders in cancer patients and current therapeutic approaches: a narrative review of an understudied topic in supportive care

  • 期刊论文

  • 发表日期：

    2025年11月7日

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  • Andrei Barasch,
  • Joel B. Epstein

摘要

Background

Despite being among the most common cancer treatment-related side effects, taste disorders have received limited study, and their management remains challenging. Recent data have associated dysgeusia with decreased quality of life and increased mortality. We discuss here the state of the science on this topic and address clinical concerns and understudied therapeutics, with the aim of stressing the importance of this side effect and the need for effective treatment.

Methods

We selected extant articles covering cancer therapy-associated dysgeusia in English language peer-reviewed literature from PubMed, Medline, Cochrane Library, and Scopus databases. We identified 368 articles, of which 92 were reviewed in detail. The relevant publications have described heterogeneous populations and a multitude of clinical characteristics. The mechanisms of altered taste perception in cancer populations have not been completely elucidated, which in turn has impaired the development of potential interventions, including prevention and management.

Conclusion

Dysgeusia in cancer patients may be more relevant to treatment success and quality of life than previously accepted. Unfortunately, this topic has not been adequately addressed and requires further study.