<p>Recent evidence from the CHALLENGE trial confirms that structured exercise can significantly improve survival outcomes in colon cancer survivors, reinforcing the principle that exercise is medicine. However, implementing personalized and scalable rehabilitation programs remains challenging. This paper explores how artificial intelligence (AI), when integrated with the International Classification of Functioning, Disability and Health (ICF) framework, can transform cancer rehabilitation through personalized exercise prescriptions, real-time monitoring, virtual coaching, and data-driven decision-making. We also discuss the role of emerging technologies such as virtual reality, wearables, and telehealth in expanding access to care. While limitations regarding data bias, equity, and regulation persist, strategic research and implementation efforts are essential. A multidisciplinary, patient-centered approach is needed to harness AI’s potential in the era of digital health.</p>