Purpose <p>This study aimed to examine the effects of taste and smell changes experienced by individuals undergoing chemotherapy on their nutritional status and quality of life.</p> Methods <p>This descriptive and cross-sectional study was conducted with 123 individuals receiving outpatient chemotherapy in a medical oncology clinic. Data were collected through face-to-face interviews using the General Information Form, Taste and Smell Dysfunction Scale (TSS), Mini Nutritional Assessment (MNA), and Functional Assessment of Cancer Therapy – General (FACT-G). Data were analyzed by frequency analysis, regression, and correlation analysis.</p> Results <p>A moderate negative correlation was found between total TSS scores and MNA total scores. Regression analysis showed that taste and smell dysfunction significantly affected nutritional status, but no significant effect was seen on quality of life scores.</p> Conclusion <p>Taste and smell dysfunctions, particularly taste alterations, significantly impair nutritional status in individuals undergoing chemotherapy. While certain aspects of quality of life, such as physical and social well-being, showed moderate associations with sensory changes, no significant impact was observed on overall quality of life scores.</p>