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Purpose <p>Oncology patients may require long-term treatment adherence and may face additional challenges to adherence during national crises. This study investigated changes in treatment adherence among breast cancer patients before and during the COVID-19 pandemic.</p> Methods <p>A historical prospective study was conducted using electronic medical records of adult breast cancer patients in the post-acute treatment phase; those receiving preventive oral monotherapy were analyzed. Adherence was assessed using the proportion of days covered (PDC).</p> Results <p>The pre-pandemic baseline PDC among 4274 patients was 78.5%. During the four COVID-19 waves (Feb 2020–Oct 2021), patients with low pre-pandemic adherence (PDC &lt; 75%) showed a significant increase in adherence (from 59 to 77%), while those with high pre-pandemic adherence (PDC &lt; 75%) experienced a decline (from 94 to 88%). A statistically significant decline was observed from wave 1 (85.69%) to wave 4 (80.69%), <i>p &lt;&#xa0;</i>0.001  . Older age was associated with higher adherence (<i>p</i>.(0.001 &gt; Patients vaccinated during the third wave exhibited a significant decline in adherence between the first and fourth waves (<i>p&#xa0;&lt;&#xa0;</i>0.001).</p> Conclusions <p>This study emphasizes the need to monitor and support medication adherence among patients with chronic oncology conditions during health crises. The COVID-19 pandemic revealed shifts in adherence patterns, highlighting the urgency of improving healthcare preparedness, enhancing access to services, and ensuring treatment continuity in future emergencies.</p>

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The impact of COVID-19 pandemic on treatment adherence of patients with breast cancer

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年6月7日

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  • Nurit Betzer Lavee,
  • Micha Barchana,
  • Tuvia Baevsky,
  • Israel Yoles

摘要

Purpose

Oncology patients may require long-term treatment adherence and may face additional challenges to adherence during national crises. This study investigated changes in treatment adherence among breast cancer patients before and during the COVID-19 pandemic.

Methods

A historical prospective study was conducted using electronic medical records of adult breast cancer patients in the post-acute treatment phase; those receiving preventive oral monotherapy were analyzed. Adherence was assessed using the proportion of days covered (PDC).

Results

The pre-pandemic baseline PDC among 4274 patients was 78.5%. During the four COVID-19 waves (Feb 2020–Oct 2021), patients with low pre-pandemic adherence (PDC < 75%) showed a significant increase in adherence (from 59 to 77%), while those with high pre-pandemic adherence (PDC < 75%) experienced a decline (from 94 to 88%). A statistically significant decline was observed from wave 1 (85.69%) to wave 4 (80.69%), p < 0.001  . Older age was associated with higher adherence (p.(0.001 > Patients vaccinated during the third wave exhibited a significant decline in adherence between the first and fourth waves (p < 0.001).

Conclusions

This study emphasizes the need to monitor and support medication adherence among patients with chronic oncology conditions during health crises. The COVID-19 pandemic revealed shifts in adherence patterns, highlighting the urgency of improving healthcare preparedness, enhancing access to services, and ensuring treatment continuity in future emergencies.