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Objective <p>To evaluate the ability of infection indicators to predict the prognosis of sepsis patients with tumor.</p> Methods <p>A total of 317 patients admitted to ICU from January 1, 2021 to June 30, 2021 were enrolled. Among them, 163 patients were infected during peri-operative period, and 98 patients were ultimately diagnosed with sepsis. The infection indicators were analyzed for prediction of sepsis prognosis.</p> Results <p>Comparison of infection indicators between sepsis and non-sepsis patients showed that procalcitonin (PCT) and interleukin-6 (IL-6) showed significant changes in sepsis patients (<i>p</i> &lt; 0.05), and PCT combined with IL-6 significantly improved the specificity of early screening for sepsis with the highest positivity predictive value for sepsis. A combination of PCT &gt; 5.965&#xa0;ng/mL and IL-6 &gt; 2808&#xa0;pg/mL was associated with poor prognosis. Peak value combinations of PCT and IL-6 for prediction specificity, positive predictive value, and negative predictive value were 0.935, 0.692, and 0.682, respectively.</p> Conclusion <p>Abnormal increase of PCT and IL-6 has a good early warning effect on sepsis in cancer patients, and the combination of PCT and IL-6 can improve predictive specificity and increase positive predictive ability of sepsis diagnosis. PCT combined with IL-6 shows the value in predicting the prognosis of sepsis patients with cancer.&#xa0;</p>

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Procalcitonin and interleukin- 6 in predicting prognosis of sepsis patients with cancer

  • 期刊论文

  • 发表日期：

    2025年4月22日

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  • Yang lyu,
  • Tao Han,
  • Zhen Zhang,
  • Yulin Wu,
  • Qingpei Guan,
  • Enlyu Hong,
  • Wenbin Gao,
  • Donghao Wang,
  • Jia Lu

摘要

Objective

To evaluate the ability of infection indicators to predict the prognosis of sepsis patients with tumor.

Methods

A total of 317 patients admitted to ICU from January 1, 2021 to June 30, 2021 were enrolled. Among them, 163 patients were infected during peri-operative period, and 98 patients were ultimately diagnosed with sepsis. The infection indicators were analyzed for prediction of sepsis prognosis.

Results

Comparison of infection indicators between sepsis and non-sepsis patients showed that procalcitonin (PCT) and interleukin-6 (IL-6) showed significant changes in sepsis patients (p < 0.05), and PCT combined with IL-6 significantly improved the specificity of early screening for sepsis with the highest positivity predictive value for sepsis. A combination of PCT > 5.965 ng/mL and IL-6 > 2808 pg/mL was associated with poor prognosis. Peak value combinations of PCT and IL-6 for prediction specificity, positive predictive value, and negative predictive value were 0.935, 0.692, and 0.682, respectively.

Conclusion

Abnormal increase of PCT and IL-6 has a good early warning effect on sepsis in cancer patients, and the combination of PCT and IL-6 can improve predictive specificity and increase positive predictive ability of sepsis diagnosis. PCT combined with IL-6 shows the value in predicting the prognosis of sepsis patients with cancer.