Scholarlink

Background <p>Studies have shown inconsistent associations between quality of life (QoL) and survival in patients with lung cancer (LC).</p> Objective <p>To assess the association between baseline functioning scales from the EORTC QoL Questionnaire Core 30 (QLQ-C30) and overall survival in patients with LC by conducting a meta-analysis.</p> Methods <p>Two independent authors searched PubMed and Embase databases using the following PECOS criteria: population (patients with pathological diagnosis of LC), exposure (poor health-related QoL, as measured by the functioning scales of EORTC QLQ-C30), comparator (better QoL), outcomes (overall survival), and study design (cohort studies).</p> Results <p>Sixteen studies with 9429 patients were identified. Compared to the highest scores, the lowest scores on the global QoL (hazard ratios [HR] 1.59; 95% confidence intervals [CI] 1.38–1.84), physical functioning (HR 1.58; 95% CI 1.24–2.03), role functioning (HR 1.43; 95% CI 1.19–1.73), and emotional functioning (HR 1.29; 95% CI 1.05–1.60) scales significantly predicted poorer overall survival. A 10-point increase in the global QoL, physical functioning, and role functioning scales was associated with a reduced risk of mortality (HR 0.87; 95% CI 0.84–0.91, HR 0.88; 95% CI 0.85–0.92, and HR 0.93; 95% CI 0.87–0.99, respectively). However, 10–point increases in the emotional functioning (HR 0.97; 95% CI 0.92–1.01), cognitive functioning (HR 0.97; 95% CI 0.95–1.00), and social functioning (HR 0.95; 95% CI 0.90–1.01) scales did not significantly predict overall survival.</p> Conclusions <p>Baseline QoL, specifically lower scores on the global QoL, physical functioning, and role functioning scales of the EORTC QLQ-C30, significantly predicts poorer overall survival in patients with LC.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Baseline functioning scales of quality of life (EORTC QLQ-C30) as a predictor of overall survival in patients with lung cancer: a meta-analysis

  • 期刊论文

  • 发表日期：

    2025年4月9日

查看全文
  • Ye Zang,
  • Wei Xu,
  • Yue Qiu,
  • Dandan Gong,
  • Yu Fan

摘要

Background

Studies have shown inconsistent associations between quality of life (QoL) and survival in patients with lung cancer (LC).

Objective

To assess the association between baseline functioning scales from the EORTC QoL Questionnaire Core 30 (QLQ-C30) and overall survival in patients with LC by conducting a meta-analysis.

Methods

Two independent authors searched PubMed and Embase databases using the following PECOS criteria: population (patients with pathological diagnosis of LC), exposure (poor health-related QoL, as measured by the functioning scales of EORTC QLQ-C30), comparator (better QoL), outcomes (overall survival), and study design (cohort studies).

Results

Sixteen studies with 9429 patients were identified. Compared to the highest scores, the lowest scores on the global QoL (hazard ratios [HR] 1.59; 95% confidence intervals [CI] 1.38–1.84), physical functioning (HR 1.58; 95% CI 1.24–2.03), role functioning (HR 1.43; 95% CI 1.19–1.73), and emotional functioning (HR 1.29; 95% CI 1.05–1.60) scales significantly predicted poorer overall survival. A 10-point increase in the global QoL, physical functioning, and role functioning scales was associated with a reduced risk of mortality (HR 0.87; 95% CI 0.84–0.91, HR 0.88; 95% CI 0.85–0.92, and HR 0.93; 95% CI 0.87–0.99, respectively). However, 10–point increases in the emotional functioning (HR 0.97; 95% CI 0.92–1.01), cognitive functioning (HR 0.97; 95% CI 0.95–1.00), and social functioning (HR 0.95; 95% CI 0.90–1.01) scales did not significantly predict overall survival.

Conclusions

Baseline QoL, specifically lower scores on the global QoL, physical functioning, and role functioning scales of the EORTC QLQ-C30, significantly predicts poorer overall survival in patients with LC.