Purpose <p>There is increased demand for lifestyle interventions earlier on the cancer continuum (i.e., during curative-intent treatment). To address this need, researchers face unique challenges intervening in the short period of time after diagnosis, but before initiation of chemotherapy and/or surgery. During the peak of the COVID-19 pandemic, transitions to remote/digital platforms became both mandatory and immediate.</p> Methods <p>This case study details the rapid transition to a remote/digital study embraced by our team as we recruited patients newly diagnosed with breast cancer to a pilot study. The pilot’s purpose was to characterize the relationships between physical activity (PA) and cognitive and mental health during breast cancer treatment.</p> Results <p>We reflect on the lessons learned during this pilot study with a particular focus on three emergent challenges: digital data collection, recruitment during active breast cancer treatment, and participant burden. We used a systematic implementation framework to track adaptations made to meet the evolving needs of patients and clinicians, while adhering to institutional protocols.</p> Conclusions <p>This case study provides important insights into the delicate balance between patient, clinician, and institutional needs in the breast cancer setting, particularly when delivering digital interventions during treatment.</p> Implications for cancer survivors <p>Careful attention should be paid to protocols for remote research to ensure that it is feasible, acceptable, and rigorous for all cancer survivors.</p>