Purpose <p>The symptom representations (i.e., beliefs and attitudes) that people with cancer hold about their symptom experience can impact how they self-manage their symptoms. Having two or more chronic conditions (multimorbidity) can complicate illness representations. Little is known about symptom representations in people with cancer and multimorbidity.</p> Methods <p>This qualitative descriptive study was conducted with a sample of adults with a diagnosis of cancer and at least one additional chronic condition. Semi-structured interviews were conducted to understand their symptom representations. Leventhal’s Common-Sense Model of Illness Representations (i.e., <i>identity</i>, <i>consequences, cure/control</i>, <i>timeline</i>, and <i>cause</i>) provided the guiding framework.&#xa0;A qualitative thematic analysis was used to identify codes, themes, and subthemes.</p> Results <p>The mean age of the participants (<i>n</i> = 17) was 62.1&#xa0;years and&#xa0;primary cancer sites were gastrointestinal,&#xa0;thoracic,&#xa0;or&#xa0;head/neck. Five themes were identified: (1) perceiving and living with symptoms, (2) being unable to do things, (3) self-management behaviors, (4) domino theory, and (5) a side effect of conditions. These themes aligned with Leventhal’s Common-Sense Model dimensions. The interaction among diagnoses and multimorbidity was identified by a minority of participants.</p> Conclusion <p>People with cancer and multimorbidity described symptom representations primarily in the context of cancer. Consistent with previous research, symptoms negatively impacted their lives, and their representations include an understanding of how symptoms interact. Few participants described their symptoms within the larger context of multimorbidity. Future research is needed to determine how symptom representations impact their communication patterns with providers and coping behaviors.</p>