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Objective <p>To compare the treatment of osteoradionecrosis (ORN) using a protocol that incorporates antimicrobial photodynamic therapy with a conventional treatment protocol.</p> Methodology <p>This retrospective study analyzed 55 patients diagnosed with ORN at a reference hospital between 2002 and 2021. Patients were treated using two different clinical protocols. Clinical treatment success was defined as the epithelialization of the ORN lesion, along with the absence of pain and local infection.</p> Results <p>A total of 53 ORN lesions were included, with a median development time of 30&#xa0;months. The patient cohort was predominantly male (83.02%), with a median age of 58&#xa0;years. The main causes of ORN were prosthetic trauma (28.30%) and dental extractions due to infection (32.07%). Good oral hygiene and hygiene of the lesion were identified as protective factors for achieving clinical success, with a significant correlation to lesion epithelialization (<i>p</i> ≤ 0.0001). ORN developed more rapidly in tumors of the oral cavity, with a median time of 8&#xa0;months, compared to oropharyngeal tumors, which had a median time of 39&#xa0;months (<i>p</i> = 0.01).</p> Conclusion <p>The proposed treatment protocol, which includes antimicrobial photodynamic therapy, demonstrated greater effectiveness compared to the conventional protocol, achieving clinical success in 75% of the lesions analyzed in a shorter timeframe (<i>p</i> ≤ 0.0001). Additionally, maintaining proper oral and lesion hygiene is crucial for successful outcomes, and ORN develops more rapidly in patients with oral cavity tumors.</p>

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Effectiveness of a protocol with antimicrobial photodynamic therapy for treating osteoradionecrosis: a retrospective study

  • 期刊论文

  • 发表日期：

    2025年1月4日

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  • Júlia Lopes Ferigatto,
  • Fábio Luiz Coracin,
  • Hélio Massaiochi Tanimoto,
  • Vivian Palata Viola,
  • Victor Tieghi-Neto,
  • Diogo Dias Prado,
  • Wellinton Yoshio Hirai,
  • Valiana Alves Teodoro,
  • Fabiana Lima Vazquez,
  • Simone Hassan Khatib Rios

摘要

Objective

To compare the treatment of osteoradionecrosis (ORN) using a protocol that incorporates antimicrobial photodynamic therapy with a conventional treatment protocol.

Methodology

This retrospective study analyzed 55 patients diagnosed with ORN at a reference hospital between 2002 and 2021. Patients were treated using two different clinical protocols. Clinical treatment success was defined as the epithelialization of the ORN lesion, along with the absence of pain and local infection.

Results

A total of 53 ORN lesions were included, with a median development time of 30 months. The patient cohort was predominantly male (83.02%), with a median age of 58 years. The main causes of ORN were prosthetic trauma (28.30%) and dental extractions due to infection (32.07%). Good oral hygiene and hygiene of the lesion were identified as protective factors for achieving clinical success, with a significant correlation to lesion epithelialization (p ≤ 0.0001). ORN developed more rapidly in tumors of the oral cavity, with a median time of 8 months, compared to oropharyngeal tumors, which had a median time of 39 months (p = 0.01).

Conclusion

The proposed treatment protocol, which includes antimicrobial photodynamic therapy, demonstrated greater effectiveness compared to the conventional protocol, achieving clinical success in 75% of the lesions analyzed in a shorter timeframe (p ≤ 0.0001). Additionally, maintaining proper oral and lesion hygiene is crucial for successful outcomes, and ORN develops more rapidly in patients with oral cavity tumors.