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Background <p>Genital infections caused by <i>Mycoplasma hominis</i> and <i>Ureaplasma urealyticum</i> are increasingly linked to female infertility, yet their epidemiology and resistance patterns remain poorly characterized in low-resource settings.</p> Objective <p>This study aimed to determine the prevalence, antimicrobial resistance (AMR) profiles, and risk factors of <i>M.&#xa0;hominis</i> and <i>U.&#xa0;urealyticum</i> infections among infertile women in Akbou, Algeria.</p> Methods <p>In this cross-sectional analysis (February–July 2024), cervicovaginal swabs from 79 infertile women were tested using the MYCOFAST® RevolutioN&#xa0;2 system. Demographic, clinical, and reproductive data were collected via structured questionnaires. Statistical analyses included χ<sup>2</sup>-testsand logistic regression.</p> Results <p>The overall infection prevalence was 37.9% (<i>n</i> = 30), with <i>U.&#xa0;urealyticum</i> (17.7%), <i>M.&#xa0;hominis</i> (13.9%), and co-infections (6.3%) predominating. Infections peaked in women aged 31–35&#xa0;years (63.3%). Resistance to tetracycline was high (<i>U.&#xa0;urealyticum</i>: 71.4%; <i>M.&#xa0;hominis</i>: 54.5%), while doxycycline and clindamycin retained full efficacy. Significant risk factors included prior abortion (adjusted odds ratio, OR = 4.2, <i>p</i> &lt; 0.001), STI history (OR = 3.8, <i>p</i> &lt; 0.001), and artificial insemination (OR = 2.9, <i>p</i> = 0.018).</p> Conclusion <p>The high prevalence of genital <i>Mycoplasma</i> infections and emerging AMR in Algeria underscores the need for routine screening, updated treatment guidelines, and targeted antimicrobial stewardship programs to safeguard reproductive health.</p>

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Emerging antimicrobial resistance and high prevalence of genital Mycoplasma hominis and Ureaplasma urealyticum infections among infertile women in Algeria

  • 期刊论文

  • 发表日期：

    2025年7月23日

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  • Assia Mairi,
  • Nasir Adam Ibrahim,
  • Thagrawla Idres,
  • Nosiba S. Basher,
  • Ahlam Smaili,
  • Takfarinas Idres,
  • Abdelaziz Toutati

摘要

Background

Genital infections caused by Mycoplasma hominis and Ureaplasma urealyticum are increasingly linked to female infertility, yet their epidemiology and resistance patterns remain poorly characterized in low-resource settings.

Objective

This study aimed to determine the prevalence, antimicrobial resistance (AMR) profiles, and risk factors of M. hominis and U. urealyticum infections among infertile women in Akbou, Algeria.

Methods

In this cross-sectional analysis (February–July 2024), cervicovaginal swabs from 79 infertile women were tested using the MYCOFAST® RevolutioN 2 system. Demographic, clinical, and reproductive data were collected via structured questionnaires. Statistical analyses included χ2-testsand logistic regression.

Results

The overall infection prevalence was 37.9% (n = 30), with U. urealyticum (17.7%), M. hominis (13.9%), and co-infections (6.3%) predominating. Infections peaked in women aged 31–35 years (63.3%). Resistance to tetracycline was high (U. urealyticum: 71.4%; M. hominis: 54.5%), while doxycycline and clindamycin retained full efficacy. Significant risk factors included prior abortion (adjusted odds ratio, OR = 4.2, p < 0.001), STI history (OR = 3.8, p < 0.001), and artificial insemination (OR = 2.9, p = 0.018).

Conclusion

The high prevalence of genital Mycoplasma infections and emerging AMR in Algeria underscores the need for routine screening, updated treatment guidelines, and targeted antimicrobial stewardship programs to safeguard reproductive health.