<p>Soldiers working in cold zones and Arctic regions face physiological challenges that lead to hypothermia, frostbite, and cold-induced conditions, which lowers their chances of survival and operational effectiveness. Nanomedicine is the innovative approach in drug delivery and the development of nanomaterials and diagnostic tools to produce ground-breaking solutions. This paper reviews advancements in thermoregulation control using nanotechnology, hypothermia treatment using nanoparticles, protective solutions for treating frostbite, and wearable nanosensors to investigate the current nanomedicine advancements applied to military cold-zone mission. AI technology integrated with nanotechnology enables clinical staff to provide personal care, diagnosis of diseases at an early stage and manage them effectively in extreme cold conditions. The current research innovations suggest connecting AI to the development of regenerative nanomedicine and diagnostic systems, as well as to standard protocols for nanomedical interventions that require international cooperation. Army protection has been improved by investigating previous military incidents and incorporating advancements in modern nanomedicine formulations. Advancements in modern medical technology offer significant opportunities to increase military operation success and readiness within extremely cold environments through superior medical equipment provided to army.</p> Graphical abstract <p></p>