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Background <p>Neonates with kidney failure require placement of a peritoneal dialysis catheter (PD–C) shortly after birth. PD–C malfunction and peritonitis, both common in this population, are associated with PD failure. The aim of this study was to describe our center’s PD–C-related practices and outcomes in neonates with kidney failure.</p> Methods <p>We performed a retrospective chart review of neonates who required kidney replacement therapy (KRT) within the first 30&#xa0;days of life from 01/2018–12/2023. We evaluated for PD–C duration, PD–C replacement or revision, and peritonitis.</p> Results <p>Twenty-four neonates had PD–C placed for chronic dialysis at a median of 9.7&#xa0;days and 3&#xa0;kg. Peritoneal dialysis (PD) was initiated a median of 14&#xa0;days after PD–C placement, at a median age of 26.5&#xa0;days. During a median follow-up time of 26.2&#xa0;months, there were 42 PD–Cs tracked. Initial PD–C lasted a median of 355&#xa0;days (IQR 165–632, range 50–953). Reasons for removal of initial PD–C included mechanical complications (38%), kidney transplant (25%), and infection (21%). There were 44 episodes of peritonitis in 19 patients. Seventeen of these episodes (39%) occurred within four weeks of a surgical procedure, despite all patients but one receiving perioperative antibiotic prophylaxis for all surgical procedures. The overall rate of peritonitis was 0.34 per 100-catheter days.</p> Conclusions <p>PD–C complications are common in this highly complex population, despite mitigation attempts with perioperative antibiotics. Future work should focus on neonatal-specific recommendations for surgery timings and prophylaxis to reduce the risk of infection and PD failure in the neonatal kidney failure population.</p> Graphical abstract <p></p>

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Peritoneal dialysis catheter complications in neonates with kidney failure

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月1日

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  • Shannon Reinert,
  • Maanasa Yarlagadda,
  • Alexander Bondoc,
  • Donna Claes,
  • Stefanie Riddle,
  • Meredith P. Schuh

摘要

Background

Neonates with kidney failure require placement of a peritoneal dialysis catheter (PD–C) shortly after birth. PD–C malfunction and peritonitis, both common in this population, are associated with PD failure. The aim of this study was to describe our center’s PD–C-related practices and outcomes in neonates with kidney failure.

Methods

We performed a retrospective chart review of neonates who required kidney replacement therapy (KRT) within the first 30 days of life from 01/2018–12/2023. We evaluated for PD–C duration, PD–C replacement or revision, and peritonitis.

Results

Twenty-four neonates had PD–C placed for chronic dialysis at a median of 9.7 days and 3 kg. Peritoneal dialysis (PD) was initiated a median of 14 days after PD–C placement, at a median age of 26.5 days. During a median follow-up time of 26.2 months, there were 42 PD–Cs tracked. Initial PD–C lasted a median of 355 days (IQR 165–632, range 50–953). Reasons for removal of initial PD–C included mechanical complications (38%), kidney transplant (25%), and infection (21%). There were 44 episodes of peritonitis in 19 patients. Seventeen of these episodes (39%) occurred within four weeks of a surgical procedure, despite all patients but one receiving perioperative antibiotic prophylaxis for all surgical procedures. The overall rate of peritonitis was 0.34 per 100-catheter days.

Conclusions

PD–C complications are common in this highly complex population, despite mitigation attempts with perioperative antibiotics. Future work should focus on neonatal-specific recommendations for surgery timings and prophylaxis to reduce the risk of infection and PD failure in the neonatal kidney failure population.

Graphical abstract