Scholarlink

Background <p>Neonatal acute kidney injury (AKI) is a frequent and severe complication in critically ill newborns. The STARZ score was originally developed and validated in the Indian population to stratify AKI risk during the first week of hospitalization, with limited validation in other settings. This study aimed to evaluate its predictive performance for AKI and mortality at two timepoints during early Neonatal Intensive Care Unit (NICU) hospitalization and to validate it in our setting.</p> Methods <p>A prospective cohort study was conducted in the NICU of Guillermo Grant Benavente Hospital, Chile, between August 2023 and April 2024. Neonates ≥ 25&#xa0;weeks gestational age and ≥ 500&#xa0;g birth weight were included. The STARZ score was calculated at 12 and 48–72&#xa0;h post-admission. The analyses included logistic regression, ROC curves, and reliability testing.</p> Results <p>Of 113 neonates, 19 (16.8%) developed AKI. AKI was significantly associated with gestational age &lt; 29&#xa0;weeks and birth weight &lt; 1000&#xa0;g. The STARZ score demonstrated modest discriminatory capacity for AKI, with an AUC of 0.66 at 12&#xa0;h and 0.72 at 48–72&#xa0;h, with no significant differences observed between time points. For mortality, the score yielded an AUC of 0.91.</p> Conclusions <p>The STARZ score showed lower predictive performance for AKI than in the original reports, while its association with mortality should be interpreted cautiously, as it may reflect AKI severity. These findings highlight the need to validate and adapt clinical risk scores across settings and develop future tools incorporating early and sensitive biomarkers for improved risk stratification.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Efficacy of the STARZ stratification score in determining the risk of acute kidney injury in critically ill neonates

  • 期刊论文

  • 发表日期：

    2026年2月1日

查看全文
  • María Nicole Bascur Postel,
  • Aldo Bancalari,
  • Iván Rodríguez-Núñez,
  • Valentina Palma,
  • Prisila Nicolás,
  • Gonzalo Mayorga,
  • Gloria Irribarra,
  • Macarena Sandoval

摘要

Background

Neonatal acute kidney injury (AKI) is a frequent and severe complication in critically ill newborns. The STARZ score was originally developed and validated in the Indian population to stratify AKI risk during the first week of hospitalization, with limited validation in other settings. This study aimed to evaluate its predictive performance for AKI and mortality at two timepoints during early Neonatal Intensive Care Unit (NICU) hospitalization and to validate it in our setting.

Methods

A prospective cohort study was conducted in the NICU of Guillermo Grant Benavente Hospital, Chile, between August 2023 and April 2024. Neonates ≥ 25 weeks gestational age and ≥ 500 g birth weight were included. The STARZ score was calculated at 12 and 48–72 h post-admission. The analyses included logistic regression, ROC curves, and reliability testing.

Results

Of 113 neonates, 19 (16.8%) developed AKI. AKI was significantly associated with gestational age < 29 weeks and birth weight < 1000 g. The STARZ score demonstrated modest discriminatory capacity for AKI, with an AUC of 0.66 at 12 h and 0.72 at 48–72 h, with no significant differences observed between time points. For mortality, the score yielded an AUC of 0.91.

Conclusions

The STARZ score showed lower predictive performance for AKI than in the original reports, while its association with mortality should be interpreted cautiously, as it may reflect AKI severity. These findings highlight the need to validate and adapt clinical risk scores across settings and develop future tools incorporating early and sensitive biomarkers for improved risk stratification.

Graphical abstract