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Background <p>Acute kidney injury (AKI) is a serious complication of pediatric cancer treatment that is suggested to increase the risk of chronic kidney disease (CKD). Children with a kidney tumor may be at particular risk. This study aimed to determine the incidence and risk factors of AKI and its association with CKD during pediatric kidney tumor treatment.</p> Methods <p>We analyzed data from a prospective national cohort of patients ≤ 18&#xa0;years old diagnosed with a kidney tumor between 2015 and 2021 in the Princess Máxima Center for Pediatric Oncology in the Netherlands. AKI was defined according to KDIGO criteria. CKD was assessed 1&#xa0;year post-treatment based on proteinuria and/or decreased estimated glomerular filtration rate (eGFR).</p> Results <p>Of 147 patients, we observed AKI in 104 patients (71%) during therapy. AKI occurred most often within 48&#xa0;h after tumor nephrectomy (88/104), while the rest had non-nephrectomy-related AKI from multifactorial causes. Sixteen patients experienced more than one AKI episode, and 92/104 episodes were reversible. Patients who developed AKI had a higher eGFR prior to surgery compared to those who did not develop AKI. CKD was observed in 16/120 patients (13%). Risk factors for developing CKD included the occurrence of at least 1 AKI event, the use of a &gt; 3-drug regimen, and a lower eGFR at the start of treatment.</p> Conclusion <p>The high incidence of AKI and its association with early CKD highlights the need for early detection, prevention, and intervention strategies during pediatric kidney tumor treatment.</p> Graphical abstract <p></p>

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The incidence and outcome of acute kidney injury during pediatric kidney tumor treatment—a national cohort study

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年2月19日

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  • Paulien A. M. A. Raymakers-Janssen,
  • Gerrit van den Berg,
  • Marc R. Lilien,
  • Inge A. van Kessel,
  • Alida F. W. van der Steeg,
  • Marc H. W. A. Wijnen,
  • Mieke I. Triest,
  • Sophie E. van Peer,
  • Marjolijn C. J. Jongmans,
  • Harm van Tinteren,
  • Geert O. Janssens,
  • Marta Fiocco,
  • Roelie M. Wösten-van Asperen,
  • Marry M. van den Heuvel-Eibrink

摘要

Background

Acute kidney injury (AKI) is a serious complication of pediatric cancer treatment that is suggested to increase the risk of chronic kidney disease (CKD). Children with a kidney tumor may be at particular risk. This study aimed to determine the incidence and risk factors of AKI and its association with CKD during pediatric kidney tumor treatment.

Methods

We analyzed data from a prospective national cohort of patients ≤ 18 years old diagnosed with a kidney tumor between 2015 and 2021 in the Princess Máxima Center for Pediatric Oncology in the Netherlands. AKI was defined according to KDIGO criteria. CKD was assessed 1 year post-treatment based on proteinuria and/or decreased estimated glomerular filtration rate (eGFR).

Results

Of 147 patients, we observed AKI in 104 patients (71%) during therapy. AKI occurred most often within 48 h after tumor nephrectomy (88/104), while the rest had non-nephrectomy-related AKI from multifactorial causes. Sixteen patients experienced more than one AKI episode, and 92/104 episodes were reversible. Patients who developed AKI had a higher eGFR prior to surgery compared to those who did not develop AKI. CKD was observed in 16/120 patients (13%). Risk factors for developing CKD included the occurrence of at least 1 AKI event, the use of a > 3-drug regimen, and a lower eGFR at the start of treatment.

Conclusion

The high incidence of AKI and its association with early CKD highlights the need for early detection, prevention, and intervention strategies during pediatric kidney tumor treatment.

Graphical abstract