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Background and aims <p>A clinical score model has been developed to stratify the risk of muscular injury during esophageal endoscopic submucosal dissection (ESD). This study aimed to prospectively validate the model in a multicenter cohort.</p> Methods <p>A multicenter prospective cohort analysis of esophageal ESD was conducted. Individual data on patients, lesions, and outcomes of ESD were utilized to validate the model for muscular injury risk stratification.</p> Results <p>A total of 704 patients with esophageal lesions treated by ESD across two hospitals were included in the study. Muscular injury occurred in 10.5% of low-risk and 61.5% of high-risk patients. The scoring system demonstrated good discriminatory performance, with an AUC of 0.761 (95% CI 0.713–0.809).</p> Conclusions <p>The clinical score model showed acceptable performance for muscular injury risk stratification during esophageal ESD and may support perioperative decision-making.</p> Graphical abstract <p></p>

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Prospective multicenter validation of a clinical score model for muscular injury risk stratification during esophageal endoscopic submucosal dissection

  • 期刊论文

  • 发表日期：

    2026年7月28日

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  • Zi-Han Geng,
  • Peng Lyu,
  • Lu Yao,
  • Yi-Fan Qu,
  • Yan Zhu,
  • Pei-Yao Fu,
  • Wei-Feng Chen,
  • Ping-Hong Zhou,
  • Quan-Lin Li,
  • Zu-Qiang Liu

摘要

Background and aims

A clinical score model has been developed to stratify the risk of muscular injury during esophageal endoscopic submucosal dissection (ESD). This study aimed to prospectively validate the model in a multicenter cohort.

Methods

A multicenter prospective cohort analysis of esophageal ESD was conducted. Individual data on patients, lesions, and outcomes of ESD were utilized to validate the model for muscular injury risk stratification.

Results

A total of 704 patients with esophageal lesions treated by ESD across two hospitals were included in the study. Muscular injury occurred in 10.5% of low-risk and 61.5% of high-risk patients. The scoring system demonstrated good discriminatory performance, with an AUC of 0.761 (95% CI 0.713–0.809).

Conclusions

The clinical score model showed acceptable performance for muscular injury risk stratification during esophageal ESD and may support perioperative decision-making.

Graphical abstract