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Introduction <p>Bariatric surgery yields clinically significant long-term weight loss accompanied by marked improvements in numerous weight-related comorbidities including type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea, and fatty liver disease.</p> Objective <p>This systematic review and meta-analysis aimed to evaluate the effect of (RYGB) surgery on lipid profile.</p> Data source <p>We searched PubMed, Scopus, Web of Science and Scholar from inception to May 20th, 2024.</p> Studies selection <p>Clinical studies that reported lipid profile data with a follow-up of at least 5&#xa0;years after RYGB were eligible.</p> Data extraction <p>Two independent reviewers extracted data and assessed the risk of bias.</p> Results <p>Of the 4922 articles identified from our database search, 38 studies that measured lipid profile following RYGB were identified and selected for the analysis. Compared to pre-surgery, at post-surgery follow-up of ≥ 5&#xa0;years, RYGB was associated with significant reductions in mean total cholesterol (TC) (WMD: −&#xa0;17.95&#xa0;mg/dl, 95% CI: −&#xa0;22.68, −&#xa0;13.22, 95% PI: −&#xa0;46.18, 10.27 p &lt; 0.001; I<sup>2</sup>:92.3), LDL-cholesterol (WMD: −&#xa0;18.55&#xa0;mg/dl, 95% CI: -21.85, -15.25, 95% PI: −&#xa0;39.01, 1.92 p &lt; 0.001; I<sup>2</sup>:91.8), and triglycerides (WMD: −&#xa0;60.76&#xa0;mg/dl, 95% CI: −&#xa0;66.29, −&#xa0;55.22, 95% PI: −&#xa0;91.24, −&#xa0;30.27 p &lt; 0.001; I<sup>2</sup>:83.7), and increase in HDL-cholesterol (WMD: 13.75&#xa0;mg/dl, 95% CI: 12.38, 15.13, 95% PI: 5.32, 22.19 p &lt; 0.001; I<sup>2</sup>:91.4).</p> Conclusion <p>RYBG is associated with clinically significant large improvements in serum lipids at a post-operative follow-up of 5&#xa0;years or more.</p>

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Long-term changes in lipid indices following Roux-en-Y gastric bypass: a meta-analysis

  • 期刊论文

  • 发表日期：

    2025年5月5日

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  • Tannaz Jamialahamdi,
  • Elaheh Mirhadi,
  • Mohammed A. Abdalla,
  • Kishore M. Gadde,
  • Wael Almahmeed,
  • Ali H. Eid,
  • Saheem Ahmad,
  • Irfan Ahmad,
  • Matthew Kroh,
  • Amirhossein Sahebkar

摘要

Introduction

Bariatric surgery yields clinically significant long-term weight loss accompanied by marked improvements in numerous weight-related comorbidities including type 2 diabetes, hypertension, dyslipidemia, obstructive sleep apnea, and fatty liver disease.

Objective

This systematic review and meta-analysis aimed to evaluate the effect of (RYGB) surgery on lipid profile.

Data source

We searched PubMed, Scopus, Web of Science and Scholar from inception to May 20th, 2024.

Studies selection

Clinical studies that reported lipid profile data with a follow-up of at least 5 years after RYGB were eligible.

Data extraction

Two independent reviewers extracted data and assessed the risk of bias.

Results

Of the 4922 articles identified from our database search, 38 studies that measured lipid profile following RYGB were identified and selected for the analysis. Compared to pre-surgery, at post-surgery follow-up of ≥ 5 years, RYGB was associated with significant reductions in mean total cholesterol (TC) (WMD: − 17.95 mg/dl, 95% CI: − 22.68, − 13.22, 95% PI: − 46.18, 10.27 p < 0.001; I2:92.3), LDL-cholesterol (WMD: − 18.55 mg/dl, 95% CI: -21.85, -15.25, 95% PI: − 39.01, 1.92 p < 0.001; I2:91.8), and triglycerides (WMD: − 60.76 mg/dl, 95% CI: − 66.29, − 55.22, 95% PI: − 91.24, − 30.27 p < 0.001; I2:83.7), and increase in HDL-cholesterol (WMD: 13.75 mg/dl, 95% CI: 12.38, 15.13, 95% PI: 5.32, 22.19 p < 0.001; I2:91.4).

Conclusion

RYBG is associated with clinically significant large improvements in serum lipids at a post-operative follow-up of 5 years or more.