Scholarlink

<p>Gastrointestinal cancers continue to pose a major global health challenge, underscoring the urgent need for novel diagnostic and therapeutic strategies. On the other hand, although polyphenols are widely recognized for their strong anticancer potential, their clinical effectiveness is hindered by poor bioavailability, instability, and rapid metabolic degradation. To overcome these limitations, the integration of nanocarrier-based delivery systems has emerged as a promising solution. These systems greatly improve the solubility, targeted delivery, and controlled release of polyphenols, which makes them more effective as medicines. This review explores the dynamic interplay between nanocarriers and polyphenols, emphasizing their combined potential in advancing gastrointestinal cancer treatment. Additionally, the review paper discusses the latest nanotechnology-driven diagnostic innovations that promise earlier cancer detection and better clinical outcomes. Leveraging polyphenol-loaded nanocarriers offers a compelling alternative to conventional therapies one that is more precise, efficient, and reduces reliance on toxic chemical agents.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Nanocarrier-mediated delivery of polyphenols: an emerging strategy for overcoming biological barriers in gastrointestinal cancer therapy

  • 期刊论文

  • 发表日期：

    2026年3月26日

查看全文
  • Sekar Vijayakumar,
  • Anbu Malar Michael,
  • Zaira I. González-Sánchez,
  • Mani Divya,
  • Esteban F. Durán-Lara,
  • Yonggang Peng,
  • Ying Yu,
  • Mingchun Li

摘要

Gastrointestinal cancers continue to pose a major global health challenge, underscoring the urgent need for novel diagnostic and therapeutic strategies. On the other hand, although polyphenols are widely recognized for their strong anticancer potential, their clinical effectiveness is hindered by poor bioavailability, instability, and rapid metabolic degradation. To overcome these limitations, the integration of nanocarrier-based delivery systems has emerged as a promising solution. These systems greatly improve the solubility, targeted delivery, and controlled release of polyphenols, which makes them more effective as medicines. This review explores the dynamic interplay between nanocarriers and polyphenols, emphasizing their combined potential in advancing gastrointestinal cancer treatment. Additionally, the review paper discusses the latest nanotechnology-driven diagnostic innovations that promise earlier cancer detection and better clinical outcomes. Leveraging polyphenol-loaded nanocarriers offers a compelling alternative to conventional therapies one that is more precise, efficient, and reduces reliance on toxic chemical agents.