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<p>The present study focused on the purification and characterization of sericin extracted from tasar cocoon degumming water, which may be used in value-added applications. The FESEM micrographs depicted the surface morphology of sericin as being rough with aggregate particles. Characterization was carried out by SDS-PAGE, FTIR spectroscopy, TGA, CHNS elemental analysis, XRD, and amino acid profiling. The SDS-PAGE analysis revealed both high- and low-molecular-weight peptides. FTIR spectra showed the presence of protein secondary structures. The thermogram indicated the material was found to be thermally stable, 50% degradation occurred at about 400&#xa0;°C. Amino acid analysis indicated the presence of 19 different amino acids, out of which serine and aspartic acid were found to be present in the highest relative abundance. Biological activities in terms of tyrosinase and elastase inhibition, antioxidant capacity, and cytotoxicity were investigated; all these tests provided promising results. These studies collectively indicate that sericin, extracted from tasar silk degumming water, is a biomaterial with immense value in diversified applications in cosmeceuticals and pharmaceuticals.</p>

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Bioprocessing of tasar cocoon degumming water for sericin extraction: structural, thermal, and biofunctional characterization

  • 期刊论文

  • 发表日期：

    2026年3月26日

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  • Karmabeer Jena,
  • Ananta Sinha,
  • Jabed Akhtar,
  • N. B. Chowdary

摘要

The present study focused on the purification and characterization of sericin extracted from tasar cocoon degumming water, which may be used in value-added applications. The FESEM micrographs depicted the surface morphology of sericin as being rough with aggregate particles. Characterization was carried out by SDS-PAGE, FTIR spectroscopy, TGA, CHNS elemental analysis, XRD, and amino acid profiling. The SDS-PAGE analysis revealed both high- and low-molecular-weight peptides. FTIR spectra showed the presence of protein secondary structures. The thermogram indicated the material was found to be thermally stable, 50% degradation occurred at about 400 °C. Amino acid analysis indicated the presence of 19 different amino acids, out of which serine and aspartic acid were found to be present in the highest relative abundance. Biological activities in terms of tyrosinase and elastase inhibition, antioxidant capacity, and cytotoxicity were investigated; all these tests provided promising results. These studies collectively indicate that sericin, extracted from tasar silk degumming water, is a biomaterial with immense value in diversified applications in cosmeceuticals and pharmaceuticals.