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<p><i>Pseudomonas aeruginosa</i> poses a significant threat in clinical settings, acting as a major causative agent of bacteremia, particularly in immunocompromised patients. Intrinsic resistance of this bacterium necessitates the urgent need for novel anti-<i>Pseudomonas</i> agents. Current therapeutic strategies are becoming increasingly inadequate, emphasizing the importance of screening studies aimed at discovering new antimicrobials that can effectively target this resilient bacterium. In this context, the exploration of herbal remedies presents a promising avenue for the development of effective antimicrobial agents. Many herbs possess bioactive compounds with documented antimicrobial properties, which could serve as potential lead substances in the quest for new treatments against <i>P. aeruginosa</i>. In the current study, the effect of the aqueous extract of 38 plant tissues, which have been introduced as an antimicrobial plant in the available publications, was investigated on <i>P. aeruginosa</i>. This study was done on a standard strain which is known as causative agent of bacteremia to find new avenues against <i>P. aeruginosa</i> bacteremia. Extracts from flower buds of <i>S. aromaticum</i>, flower of <i>P. granatum</i> L. var. pleniflora, and fruit of <i>R. coriaria</i> were found as effective against <i>P. aeruginosa</i>. Combination effect of these extracts was primarily evaluated by double well synergy test, and it was found that <i>P. granatum</i> and <i>R. coriaria</i> extracts may have additive or synergistic antimicrobial effect. More evaluations were performed via checkerboard assay. Fractional inhibitory concentration index (FICI) was calculated as 0.84 which fall within the additive range (0.5 &lt; FICI ≤ 1). These results suggest that the combination of <i>P. granatum</i> and <i>R. coriaria</i> extracts can provide a promising natural mixture with enhanced antimicrobial efficacy to treat <i>P. aeruginosa</i> bacteremia. So, it can be concluded that mixed extract is a valuable source of natural anti-<i>Pseudomonas</i> compounds which can be subjected for further studies regarding toxicity and formulation.</p>

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Antimicrobial potency and additive effect of herbal antimicrobial compounds against Pseudomonas aeruginosa, a causative agent of bacteremia

  • 期刊论文

  • 发表日期：

    2025年11月22日

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  • Alireza Ebrahiminezhad,
  • Nahid Moradi,
  • Susan Sohrabi,
  • Aydin Berenjian

摘要

Pseudomonas aeruginosa poses a significant threat in clinical settings, acting as a major causative agent of bacteremia, particularly in immunocompromised patients. Intrinsic resistance of this bacterium necessitates the urgent need for novel anti-Pseudomonas agents. Current therapeutic strategies are becoming increasingly inadequate, emphasizing the importance of screening studies aimed at discovering new antimicrobials that can effectively target this resilient bacterium. In this context, the exploration of herbal remedies presents a promising avenue for the development of effective antimicrobial agents. Many herbs possess bioactive compounds with documented antimicrobial properties, which could serve as potential lead substances in the quest for new treatments against P. aeruginosa. In the current study, the effect of the aqueous extract of 38 plant tissues, which have been introduced as an antimicrobial plant in the available publications, was investigated on P. aeruginosa. This study was done on a standard strain which is known as causative agent of bacteremia to find new avenues against P. aeruginosa bacteremia. Extracts from flower buds of S. aromaticum, flower of P. granatum L. var. pleniflora, and fruit of R. coriaria were found as effective against P. aeruginosa. Combination effect of these extracts was primarily evaluated by double well synergy test, and it was found that P. granatum and R. coriaria extracts may have additive or synergistic antimicrobial effect. More evaluations were performed via checkerboard assay. Fractional inhibitory concentration index (FICI) was calculated as 0.84 which fall within the additive range (0.5 < FICI ≤ 1). These results suggest that the combination of P. granatum and R. coriaria extracts can provide a promising natural mixture with enhanced antimicrobial efficacy to treat P. aeruginosa bacteremia. So, it can be concluded that mixed extract is a valuable source of natural anti-Pseudomonas compounds which can be subjected for further studies regarding toxicity and formulation.