<p>This study investigates the relationships between spiritual well-being, perceived social support, and psychological resilience among parents of children with special needs. Data were collected from 257 parents using the Information Form, Spiritual Well-Being Scale (SWBS), Revised Parent Social Support Scale (RPSSS), and Psychological Resilience Scale (PRS). Findings indicate that higher levels of spiritual well-being and perceived social support are associated with greater psychological resilience. Moreover, spiritual well-being contributes more substantially to resilience than perceived social support.</p><p><i>Conclusions</i>: Identifying parents’ needs and implementing appropirate interventions may contribute to&#xa0;improving their well-being and resilience. Further research with larger and more diverse samples in recommended.<Table Float="No" ID="Taba"> <tgroup cols="1"> <colspec align="left" colname="c1" colnum="1" /> <tbody> <row> <entry align="left" colname="c1"> <p><b>What is Known:</b></p> <p>•&#xa0;<i>Parents of children with special needs are at increased risk of psychological and social difficulties.</i></p> <p>• <i>Spiritual well-being and social support are important factors associated with psychological resilience.</i></p> </entry> </row> <row> <entry align="left" colname="c1"> <p><b>What is New:</b></p> <p>• <i>Spiritual well-being emerged as the strongest contributor to psychological resilience among parents of children with special needs.</i></p> <p>• <i>Addressing spiritual well-being may enhance support strategies for parents of children with special needs.</i></p> </entry> </row> </tbody> </tgroup> </Table></p>