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<p>Interventional closure of patent ductus arteriosus (PDA) in preterm infants may result in significant hemodynamic and pulmonary changes. Lung ultrasound (LU) is increasingly used to assess pulmonary aeration; however, data on early respiratory changes following PDA closure remain limited. A prospective observational study was conducted including preterm infants born at ≤ 32 weeks’ gestation with hemodynamically significant PDA undergoing surgical or catheter-based closure between May 2022 and November 2025. LU was performed the day before intervention and at 1–2 h, 6–12 h, 24 h, and 2–3 days after closure. Oxygenation (S/F ratio) and invasive mechanical ventilation (IMV) use were also evaluated. Seventeen infants were included (15 catheter-based, 2 surgical closures). A transient deterioration in oxygenation and increased odds of IMV were observed within the first hours after ductal closure. This was followed by a significant improvement in lung ultrasound score at 2–3 days.</p><p> <i>Conclusion</i>: Lung aeration improved 2–3 days after interventional PDA closure in preterm infants. Lung ultrasound may be a useful bedside tool to monitor dynamic pulmonary changes during the early post-closure period.</p>

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Lung ultrasound evolution after interventional closure of the ductus in preterm babies

  • 期刊论文

  • 发表日期：

    2026年5月20日

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  • María Arriaga-Redondo,
  • Rebeca Gregorio-Hernández,
  • Ana Rodríguez-Sánchez de la Blanca,
  • Elena Rodriguez-Corrales,
  • Sara Vigil-Vázquez,
  • Alba Pérez-Pérez,
  • Cristina Ramos-Navarro,
  • Manuel Sánchez-Luna

摘要

Interventional closure of patent ductus arteriosus (PDA) in preterm infants may result in significant hemodynamic and pulmonary changes. Lung ultrasound (LU) is increasingly used to assess pulmonary aeration; however, data on early respiratory changes following PDA closure remain limited. A prospective observational study was conducted including preterm infants born at ≤ 32 weeks’ gestation with hemodynamically significant PDA undergoing surgical or catheter-based closure between May 2022 and November 2025. LU was performed the day before intervention and at 1–2 h, 6–12 h, 24 h, and 2–3 days after closure. Oxygenation (S/F ratio) and invasive mechanical ventilation (IMV) use were also evaluated. Seventeen infants were included (15 catheter-based, 2 surgical closures). A transient deterioration in oxygenation and increased odds of IMV were observed within the first hours after ductal closure. This was followed by a significant improvement in lung ultrasound score at 2–3 days.

Conclusion: Lung aeration improved 2–3 days after interventional PDA closure in preterm infants. Lung ultrasound may be a useful bedside tool to monitor dynamic pulmonary changes during the early post-closure period.