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Abstract <p>The aim of the study was to compare the effectiveness of daycare-simulated interrupted phototherapy versus continuous phototherapy for treating neonatal jaundice. A parallel randomized controlled trial with one-to-one allocation was conducted involving low-risk jaundiced neonates. The neonates in the intervention group received 10&#xa0;h of phototherapy, while the control group received continuous phototherapy for 24&#xa0;h. Total serum bilirubin (TSB) was measured before the start of phototherapy and at 24&#xa0;h of treatment. Seventy-four neonates were recruited, and 37 neonates were randomly allocated to each group. The mean rate of fall of TSB per hour was not statistically significantly different between the intervention and control groups (1.71 versus 1.9&#xa0;µmol/L/h; <i>p</i> = 0.529). The mean of TSB post-treatment in the intervention group was higher than in the control group and statistically significant (182 versus 158&#xa0;µmol/L; <i>p</i> = 0.045) but not clinically significant, as none of the neonates required reinstitution or continuation of phototherapy.</p> <p><i>Conclusion</i>:&#xa0;Ten hours of phototherapy which could be given in daycare may be effective and safe.</p> <p><i>Trial registration</i>: This trial wasregistered with Australian New Zealand Clinical Trials (trial ID: ANZCTR 12624000860561) prospectively on 12 July 2024.<Table Float="No" ID="Taba"> <tgroup cols="2"> <colspec align="left" colname="c1" colnum="1" /> <colspec align="left" colname="c2" colnum="2" /> <tbody> <row> <entry align="left" nameend="c2" namest="c1"> <p><b>What is Known:</b></p> <p>• <i>Intermittent phototherapy is known to be as effective as continuous phototherapy.</i></p> <p><b>What is New:</b></p> <p>• <i>We designed a study in which phototherapy was interrupted after 10 h, simulating daycare phototherapy.</i></p> <p>• <i>Daycare phototherapy for 10&#xa0;h may be feasible in treating neonatal hyperbilirubinemia in low-risk neonates.</i></p> </entry> </row> </tbody> </tgroup> </Table></p>

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Daycare-simulated interrupted phototherapy for neonatal jaundice: a randomized controlled trial

  • 期刊论文

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  • 发表日期：

    2026年1月10日

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  • Jia Cheng Ong,
  • Farohah Che Mat Zain,
  • Yee Cheng Kueh,
  • Noraida Ramli,
  • Hans Van Rostenberghe,
  • Surini Yusoff

摘要

Abstract

The aim of the study was to compare the effectiveness of daycare-simulated interrupted phototherapy versus continuous phototherapy for treating neonatal jaundice. A parallel randomized controlled trial with one-to-one allocation was conducted involving low-risk jaundiced neonates. The neonates in the intervention group received 10 h of phototherapy, while the control group received continuous phototherapy for 24 h. Total serum bilirubin (TSB) was measured before the start of phototherapy and at 24 h of treatment. Seventy-four neonates were recruited, and 37 neonates were randomly allocated to each group. The mean rate of fall of TSB per hour was not statistically significantly different between the intervention and control groups (1.71 versus 1.9 µmol/L/h; p = 0.529). The mean of TSB post-treatment in the intervention group was higher than in the control group and statistically significant (182 versus 158 µmol/L; p = 0.045) but not clinically significant, as none of the neonates required reinstitution or continuation of phototherapy.

Conclusion: Ten hours of phototherapy which could be given in daycare may be effective and safe.

Trial registration: This trial wasregistered with Australian New Zealand Clinical Trials (trial ID: ANZCTR 12624000860561) prospectively on 12 July 2024.

What is Known:

• Intermittent phototherapy is known to be as effective as continuous phototherapy.

What is New:

• We designed a study in which phototherapy was interrupted after 10 h, simulating daycare phototherapy.

• Daycare phototherapy for 10 h may be feasible in treating neonatal hyperbilirubinemia in low-risk neonates.