Introduction Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood, and steroid intra-articular injections are a fundamental treatment modality among local therapeutic interventions. The aim of this systemic review was to assess the scientific evidence on the effectiveness and safety of intra-articular corticosteroids (IACS) injections, focusing on a comparative examination of the different therapeutic options. Material and methods PubMed, Scopus, and Web of Science were systematically searched from the inception until February 25, 2025, to identify observational studies presenting participants with a diagnosis of JIA, IACS injections for joints affected by arthritis as interventions, and clinical or radiological assessment of arthritis as outcomes. Conclusions Findings from this systematic review suggested that IACS injections might be effective in improving arthritis in patients affected by JIA, with good evidence of safety. Moreover, the review underlines a higher efficacy of triamcinolone hexacetonide among corticosteroids used for injections. Further studies with a higher level of evidence and more representative samples should be conducted. <Table Float="No" ID="Taba"> <tgroup cols="2"> <colspec align="left" colname="c1" colnum="1" /> <colspec align="left" colname="c2" colnum="2" /> <tbody> <row> <entry nameend="c2" namest="c1"> What is Known: • Juvenile idiopathic arthritis is the most prevalent chronic rheumatic condition in childhood and represents a major cause of disability. • The management of juvenile idiopathic arthritis involves a variety of therapeutic modalities, among which intra-articular corticosteroid injections. </entry> </row> <row> <entry nameend="c2" namest="c1"> What is New: • Intra-articular corticosteroid injections induce rapid symptom control and prolonged remission in a substantial proportion of patients. • Among different types of corticosteroids, triamcinolone hexacetonide is more effective in prolonging remission duration in JIA. </entry> </row> </tbody> </tgroup> </Table>

Effectiveness of steroid intra-articular injections on functioning in children and adolescents affected by juvenile idiopathic arthritis: a systematic review

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2025年10月20日

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Romina Gallizzi,
Rosario Francesco Dipasquale,
Alessia Mendicino,
Martina Ferrillo,
Umile Giuseppe Longo,
Daniela Concolino,
Antonio Ammendolia,
Alessandro de Sire

摘要

Introduction

Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood, and steroid intra-articular injections are a fundamental treatment modality among local therapeutic interventions. The aim of this systemic review was to assess the scientific evidence on the effectiveness and safety of intra-articular corticosteroids (IACS) injections, focusing on a comparative examination of the different therapeutic options.

Material and methods

PubMed, Scopus, and Web of Science were systematically searched from the inception until February 25, 2025, to identify observational studies presenting participants with a diagnosis of JIA, IACS injections for joints affected by arthritis as interventions, and clinical or radiological assessment of arthritis as outcomes.

Conclusions

Findings from this systematic review suggested that IACS injections might be effective in improving arthritis in patients affected by JIA, with good evidence of safety. Moreover, the review underlines a higher efficacy of triamcinolone hexacetonide among corticosteroids used for injections. Further studies with a higher level of evidence and more representative samples should be conducted.

What is Known:

• Juvenile idiopathic arthritis is the most prevalent chronic rheumatic condition in childhood and represents a major cause of disability.

• The management of juvenile idiopathic arthritis involves a variety of therapeutic modalities, among which intra-articular corticosteroid injections.

What is New:

• Intra-articular corticosteroid injections induce rapid symptom control and prolonged remission in a substantial proportion of patients.

• Among different types of corticosteroids, triamcinolone hexacetonide is more effective in prolonging remission duration in JIA.