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<p>Respiratory syncytial virus (RSV) is a leading cause of hospitalizations in young children globally. We evaluated direct medical costs, caregiver work loss, and child quality of life (QoL) impairment associated with RSV hospitalization. Children ≤ 2&#xa0;years with laboratory-confirmed RSV infection were prospectively identified between October 2020 and May 2023 at ten hospitals in Germany, Spain, Italy, France, and England. Direct costs were calculated based on country-specific unit costs per hospital day. Productivity loss and QoL impairment were ascertained by two validated, caregiver-administered instruments: 1) Work Productivity and Activity Impairment Questionnaire: Child’s Hospitalization for Respiratory Illness (WPAI:CHRI), administered before discharge and 2) TNO AZL Child Quality of Life (TAPQOL), administered at baseline (shortly after admission) and before discharge. Among 382 hospitalized children, 261 (69%) were &lt; 6&#xa0;months and 306 (80%) were previously healthy. Median length of stay was 6&#xa0;days (Interquartile Range (IQR) 4–8) and 50 (13%) were admitted to Paediatric Intensive Care Unit (PICU). Median hospital costs/admission were €4,266 (IQR 2,438–8,442), substantially varying by country (range €2,377-€8,541). Productivity loss was substantial with 129/211 (61%) employed caregivers reporting lost work-hours (mean 30.5 ± 18/admission). Child QoL was significantly reduced during RSV hospitalization in most domains, with the highest QoL impairment observed in the lung domain (mean difference 34.2 out of 100 [95% CI 30–38.4]. Conclusion: RSV hospitalization in children ≤ 2&#xa0;years was associated with significant costs and QoL impairment in five European countries, emphasizing the importance of preventing severe RSV disease.</p>

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Impact of RSV hospitalization on healthcare costs, caregivers’ productivity loss, and quality of life in children ≤ 2 years old in five European countries

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  • 发表日期：

    2025年10月25日

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  • Joanne G. Wildenbeest,
  • Louis Bont,
  • Daniela Cianci,
  • Geert W. J. Frederix,
  • Cristina Calvo,
  • Johannes Liese,
  • Renato Cutrera,
  • Chiara Azzari,
  • Jacques Brouard,
  • Federico Martinon-Torres,
  • Egbert Herting,
  • Simon B. Drysdale,
  • Ralph Epaud,
  • Atul Gupta,
  • Madelyn Ruggieri,
  • Yoonyoung Choi,
  • Celine Delestrain,
  • Mickael Shum,
  • Caroline Faucon,
  • Nicola Ullmann,
  • Anna Chiara Vittucci,
  • Clara Haug,
  • Niklas Jakobs,
  • Silvia Ricci,
  • Chiara Rubino,
  • Geraldine Engels,
  • Katharina Hecker,
  • Andrea Streng,
  • Julia Bley,
  • Natasha Thorn

摘要

Respiratory syncytial virus (RSV) is a leading cause of hospitalizations in young children globally. We evaluated direct medical costs, caregiver work loss, and child quality of life (QoL) impairment associated with RSV hospitalization. Children ≤ 2 years with laboratory-confirmed RSV infection were prospectively identified between October 2020 and May 2023 at ten hospitals in Germany, Spain, Italy, France, and England. Direct costs were calculated based on country-specific unit costs per hospital day. Productivity loss and QoL impairment were ascertained by two validated, caregiver-administered instruments: 1) Work Productivity and Activity Impairment Questionnaire: Child’s Hospitalization for Respiratory Illness (WPAI:CHRI), administered before discharge and 2) TNO AZL Child Quality of Life (TAPQOL), administered at baseline (shortly after admission) and before discharge. Among 382 hospitalized children, 261 (69%) were < 6 months and 306 (80%) were previously healthy. Median length of stay was 6 days (Interquartile Range (IQR) 4–8) and 50 (13%) were admitted to Paediatric Intensive Care Unit (PICU). Median hospital costs/admission were €4,266 (IQR 2,438–8,442), substantially varying by country (range €2,377-€8,541). Productivity loss was substantial with 129/211 (61%) employed caregivers reporting lost work-hours (mean 30.5 ± 18/admission). Child QoL was significantly reduced during RSV hospitalization in most domains, with the highest QoL impairment observed in the lung domain (mean difference 34.2 out of 100 [95% CI 30–38.4]. Conclusion: RSV hospitalization in children ≤ 2 years was associated with significant costs and QoL impairment in five European countries, emphasizing the importance of preventing severe RSV disease.