Early enteral nutrition in patients undergoing extracorporeal membrane oxygenation (ECMO) is particularly challenging due to metabolic instability, feeding intolerance, and the risk of intestinal ischemia. This study aimed to identify risk factors for gastrointestinal intolerance (GI) and necrotizing enterocolitis (NEC) in pediatric patients supported with veno-arterial (VA) or veno-venous (VV) ECMO. This monocentric and retrospective cohort study involved 127 pediatric patients who underwent ECMO in the pediatric intensive care unit of the Queen Fabiola Children’s University Hospital, Belgium, between January 2011 and December 2023. Diarrhea on Day 2 (D2) occurred in 13.7% of the VV-ECMO patients (10/73) but not in any of the VA-ECMO patients (p = 0.013). The frequencies of other gastrointestinal symptoms, such as vomiting, abdominal distension, and gastrointestinal hemorrhage, did not significantly differ between the groups during the study period. NEC occurred in 5.1% of VV-ECMO patients (4/78) and 10.2% of VA-ECMO patients (5/49) (p = 0.230). Enteral nutrition was initiated within 48 h of ECMO cannulation in 110/127 patients (86.6%). Patients who presented with gastrointestinal complications on D2 had a low lactate value at ECMO initiation (3.61 ± 0.56 mmol/l versus 5.42 ± 0.44 mmol/l (p = 0.013)) and a low PRISM (19 ± 3 versus 25 ± 1 (p = 0.033)) and PIM (12 ± 5 versus 18 ± 2 (p = 0.288)). Patients with NEC presented non significantly higher lactate levels on D0 and D2. Lactatemia was significantly lower for living patients on D0 and D2. Conclusion: This study suggests that early EN in pediatric ECMO patients should be approached with caution. Mild digestive complications can occur, and the incidence of NEC can be high. High lactate levels at ECMO cannulation appear to be associated with severe complications such as death and NEC.<Table Float="No" ID="Taba"> <tgroup cols="1"> <colspec align="left" colname="c1" colnum="1" /> <tbody> <row> <entry align="left" colname="c1"> What is Known: • Hyperlactatemia is a valuable indicator of low tissue perfusion. </entry> </row> <row> <entry align="left" colname="c1"> What is New: • The findings of this study suggest that patients who developed NEC had higher lactate levels at the time of cannulation than at the time of NEC diagnosis. • Lactatemia seems to be a risk factor for severe complications such as NEC and death rather than a risk factor for mild GI complications. </entry> </row> </tbody> </tgroup> </Table>

Lactate and gastrointestinal complications during enteral nutrition in pediatric ECMO patients: a retrospective cohort study

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发表日期：

2025年4月28日

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Bruna Pinheiro Machado,
Yadigar Ziylan,
Alexia Detheux,
Ariane Willems,
Viviane De Maertelaer,
Corinne De Laet,
Shancy Rooze

摘要

Early enteral nutrition in patients undergoing extracorporeal membrane oxygenation (ECMO) is particularly challenging due to metabolic instability, feeding intolerance, and the risk of intestinal ischemia. This study aimed to identify risk factors for gastrointestinal intolerance (GI) and necrotizing enterocolitis (NEC) in pediatric patients supported with veno-arterial (VA) or veno-venous (VV) ECMO. This monocentric and retrospective cohort study involved 127 pediatric patients who underwent ECMO in the pediatric intensive care unit of the Queen Fabiola Children’s University Hospital, Belgium, between January 2011 and December 2023. Diarrhea on Day 2 (D2) occurred in 13.7% of the VV-ECMO patients (10/73) but not in any of the VA-ECMO patients (p = 0.013). The frequencies of other gastrointestinal symptoms, such as vomiting, abdominal distension, and gastrointestinal hemorrhage, did not significantly differ between the groups during the study period. NEC occurred in 5.1% of VV-ECMO patients (4/78) and 10.2% of VA-ECMO patients (5/49) (p = 0.230). Enteral nutrition was initiated within 48 h of ECMO cannulation in 110/127 patients (86.6%). Patients who presented with gastrointestinal complications on D2 had a low lactate value at ECMO initiation (3.61 ± 0.56 mmol/l versus 5.42 ± 0.44 mmol/l (p = 0.013)) and a low PRISM (19 ± 3 versus 25 ± 1 (p = 0.033)) and PIM (12 ± 5 versus 18 ± 2 (p = 0.288)). Patients with NEC presented non significantly higher lactate levels on D0 and D2. Lactatemia was significantly lower for living patients on D0 and D2.

Conclusion: This study suggests that early EN in pediatric ECMO patients should be approached with caution. Mild digestive complications can occur, and the incidence of NEC can be high. High lactate levels at ECMO cannulation appear to be associated with severe complications such as death and NEC.

What is Known:

• Hyperlactatemia is a valuable indicator of low tissue perfusion.

What is New:

• The findings of this study suggest that patients who developed NEC had higher lactate levels at the time of cannulation than at the time of NEC diagnosis.

• Lactatemia seems to be a risk factor for severe complications such as NEC and death rather than a risk factor for mild GI complications.