The World Health Organization recommends using + 2 SD of body mass index z-score (zBMI) to define overweight/obesity (OWO) in children ages 2 to 5 years whereas + 1 SD is used as cut-point from 5 years onwards. Empirical evidence for using different cut-points across childhood is lacking. Our objective was to compare the ability of OWO in early childhood defined using zBMI cut-points at + 2 SD and + 1 SD to predict obesity at 10 years. Data from a prospective birth cohort (QLSCD) were analyzed. At ages 2.5, 3.5, and 4.5 years, children were classified as OWO based on + 2 SD and + 1 SD zBMI cut-points. At 10 years, obesity was assessed (zBMI and waist circumference). Associations between OWO (vs non-OWO) and later obesity were estimated using multivariable linear regressions. Outcome predictions for each cut-point were compared using partial eta-squared values. The sample included 1092 children (53% female). OWO in early childhood was 2–3 times more prevalent when using + 1 SD vs + 2 SD cut-points. In relation to later obesity, partial eta-squared values for both cut-points of OWO were in the small to medium effect size range (ranging from 3 to 15%), suggesting that OWO regardless of cut-point contributed only modestly to obesity measured at 10 years. However, across all time points, eta-squared values were slightly higher for OWO defined at + 1 SD vs + 2 SD, indicating a higher proportion of variance in outcomes being accounted for at zBMI + 1 SD. Conclusion: In children 2 to 5 years old, both definitions of OWO had small to modest effect sizes in relation to obesity in childhood albeit with a marginally superior predictive ability of the + 1 SD over the + 2 SD cut-point across early childhood. From a clinical perspective, using a single cut-point from early childhood onwards may be more practical to monitor growth and weight gain over time and identify children at risk of persistent obesity. <Table Float="No" ID="Taba"> <tgroup cols="1"> <colspec align="left" colname="c1" colnum="1" /> <tbody> <row> <entry align="left" colname="c1"> What is Known: • The World Health Organization recommends using zBMI cut-points at + 2 SD for children ages 2–5 years, and + 1 SD from 5 years onwards to define overweight/obesity • Research is needed to determine which zBMI cut-point (+ 2 SD or + 1 SD) in children under 5 years best predicts subsequent obesity </entry> </row> <row> <entry align="left" colname="c1"> What is New: • Both definitions of overweight/obesity in early childhood contributed modestly to obesity at 10 years, with + 1 SD being marginally more effective than + 2 SD • Using a single cut-point at + 1 SD across childhood may be more practical for monitoring growth, weight gain, and identifying children at risk of persistent obesity </entry> </row> </tbody> </tgroup> </Table>

Overweight and obesity in early childhood and obesity at 10 years of age: a comparison of World Health Organization definitions

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发表日期：

2025年3月27日

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Andraea Van Hulst,
Sophie Zheng,
Nikolas Argiropoulos,
Marina Ybarra,
Geoff D. C. Ball,
Lisa Kakinami

摘要

The World Health Organization recommends using + 2 SD of body mass index z-score (zBMI) to define overweight/obesity (OWO) in children ages 2 to 5 years whereas + 1 SD is used as cut-point from 5 years onwards. Empirical evidence for using different cut-points across childhood is lacking. Our objective was to compare the ability of OWO in early childhood defined using zBMI cut-points at + 2 SD and + 1 SD to predict obesity at 10 years. Data from a prospective birth cohort (QLSCD) were analyzed. At ages 2.5, 3.5, and 4.5 years, children were classified as OWO based on + 2 SD and + 1 SD zBMI cut-points. At 10 years, obesity was assessed (zBMI and waist circumference). Associations between OWO (vs non-OWO) and later obesity were estimated using multivariable linear regressions. Outcome predictions for each cut-point were compared using partial eta-squared values. The sample included 1092 children (53% female). OWO in early childhood was 2–3 times more prevalent when using + 1 SD vs + 2 SD cut-points. In relation to later obesity, partial eta-squared values for both cut-points of OWO were in the small to medium effect size range (ranging from 3 to 15%), suggesting that OWO regardless of cut-point contributed only modestly to obesity measured at 10 years. However, across all time points, eta-squared values were slightly higher for OWO defined at + 1 SD vs + 2 SD, indicating a higher proportion of variance in outcomes being accounted for at zBMI + 1 SD.

Conclusion: In children 2 to 5 years old, both definitions of OWO had small to modest effect sizes in relation to obesity in childhood albeit with a marginally superior predictive ability of the + 1 SD over the + 2 SD cut-point across early childhood. From a clinical perspective, using a single cut-point from early childhood onwards may be more practical to monitor growth and weight gain over time and identify children at risk of persistent obesity.

What is Known:

• The World Health Organization recommends using zBMI cut-points at + 2 SD for children ages 2–5 years, and + 1 SD from 5 years onwards to define overweight/obesity

• Research is needed to determine which zBMI cut-point (+ 2 SD or + 1 SD) in children under 5 years best predicts subsequent obesity

What is New:

• Both definitions of overweight/obesity in early childhood contributed modestly to obesity at 10 years, with + 1 SD being marginally more effective than + 2 SD

• Using a single cut-point at + 1 SD across childhood may be more practical for monitoring growth, weight gain, and identifying children at risk of persistent obesity