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<p>Proton pump inhibitors (PPIs) represent a class of drugs most prominently known for their use in acid-related disorders. Omeprazole, a drug belonging to this class, is among the top 10 most prescribed drugs in the USA. PPIs have a direct effect on the gastric pH and therefore on the gastric mucosa. This review aims to present the most common adverse effects PPIs have on the gastric mucosa in particular.</p><p><i>Conclusion</i>: PPIs affect the composition of gut and gastric microbiota and will eventually modulate the immune response.</p><p><Table Float="No" ID="Taba"> <tgroup cols="2"> <colspec align="left" colname="c1" colnum="1" /> <colspec align="left" colname="c2" colnum="2" /> <tbody> <row> <entry align="left" nameend="c2" namest="c1"> <p>What is known:</p> <p><i>• Proton-pump inhibitors are amonth the most frequent prescirbed drugs becasue of their well demonstrated efficacy in acid-related disorders.</i></p> <p><i>• Because of their mode of action and their metabolism, a large spectrum of adversee effects have been reported.</i></p> <p>What is new:</p> <p><i>• Although the well-known success of PPIs in the wide spectrum of all acid-related conditions should not refrain health care professionals to use them when indicated, insufficient attention is given to the multiple adverse effects reported for this class of drugs.</i></p> <p><i>• Well designed prospective trials collecting adverse effects are required, since most studies reporting adverse effects are retrospective, are biassed and have methodological issues.</i></p> </entry> </row> </tbody> </tgroup> </Table></p>

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Why think twice before prescribing proton pump inhibitors

  • 期刊论文

  • 发表日期：

    2025年3月5日

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  • An-Sofie Lemmens,
  • Koen Huysentruyt,
  • Yvan Vandenplas

摘要

Proton pump inhibitors (PPIs) represent a class of drugs most prominently known for their use in acid-related disorders. Omeprazole, a drug belonging to this class, is among the top 10 most prescribed drugs in the USA. PPIs have a direct effect on the gastric pH and therefore on the gastric mucosa. This review aims to present the most common adverse effects PPIs have on the gastric mucosa in particular.

Conclusion: PPIs affect the composition of gut and gastric microbiota and will eventually modulate the immune response.

What is known:

• Proton-pump inhibitors are amonth the most frequent prescirbed drugs becasue of their well demonstrated efficacy in acid-related disorders.

• Because of their mode of action and their metabolism, a large spectrum of adversee effects have been reported.

What is new:

• Although the well-known success of PPIs in the wide spectrum of all acid-related conditions should not refrain health care professionals to use them when indicated, insufficient attention is given to the multiple adverse effects reported for this class of drugs.

• Well designed prospective trials collecting adverse effects are required, since most studies reporting adverse effects are retrospective, are biassed and have methodological issues.