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<p>In the human cerebral cortex, the right hemisphere dominance of face processing has been well-established across age groups and in different clinical populations. Nevertheless, the role of handedness in this lateralization remains unclear as previous studies have yielded inconclusive results due to small sample sizes and the fact that they did not consider recent results identifying multiple face-selective regions on the fusiform gyrus (FG) that are anatomically and functionally distinct in over 1000 individuals. To address these parallel concerns, we investigated the relationship between handedness and the structural, functional, and connectivity properties of manually defined FG face-selective regions using multimodal neuroimaging data from a large sample of non-right-handers (<i>N</i> = 124)—a sample size which is 5–11 times the size of previous studies. Our careful, manual delineations of FG face-selective regions—in the spirit of “precision imaging” in the broader cognitive neuroscience and human brain mapping fields—revealed that pFus-faces/FFA-1 is more selective in the right, compared to the left, hemisphere in non-right handers, which is not the case for mFus-faces/FFA-2. Subsequent analyses relating handedness to network properties or anatomical features did not reveal any significant effects. The combination of these findings provides a foundation for implementing a precision imaging approach that is ideal for building strategies for case studies and the treatment and intervention of neurological disorders that include issues with either face perception, handedness, or both—as well as evolutionary and theoretical insights regarding hemispheric specialization of cortical function.</p>

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On handedness and the lateralization of fusiform face area(s)

  • 期刊论文

  • 发表日期：

    2025年10月27日

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  • Ruilin Zhang,
  • Xinmiao Yuan,
  • Youyi Liu,
  • Zonglei Zhen,
  • Kevin Sean Weiner

摘要

In the human cerebral cortex, the right hemisphere dominance of face processing has been well-established across age groups and in different clinical populations. Nevertheless, the role of handedness in this lateralization remains unclear as previous studies have yielded inconclusive results due to small sample sizes and the fact that they did not consider recent results identifying multiple face-selective regions on the fusiform gyrus (FG) that are anatomically and functionally distinct in over 1000 individuals. To address these parallel concerns, we investigated the relationship between handedness and the structural, functional, and connectivity properties of manually defined FG face-selective regions using multimodal neuroimaging data from a large sample of non-right-handers (N = 124)—a sample size which is 5–11 times the size of previous studies. Our careful, manual delineations of FG face-selective regions—in the spirit of “precision imaging” in the broader cognitive neuroscience and human brain mapping fields—revealed that pFus-faces/FFA-1 is more selective in the right, compared to the left, hemisphere in non-right handers, which is not the case for mFus-faces/FFA-2. Subsequent analyses relating handedness to network properties or anatomical features did not reveal any significant effects. The combination of these findings provides a foundation for implementing a precision imaging approach that is ideal for building strategies for case studies and the treatment and intervention of neurological disorders that include issues with either face perception, handedness, or both—as well as evolutionary and theoretical insights regarding hemispheric specialization of cortical function.