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<p>Did you know that there are thousands of ways to build a connectome from diffusion MRI tractography, and the choice of approach can hugely impact the final connectome and results? To name only a few: Tractography type: deterministic or probabilistic? Parcellation resolution: coarse or fine atlas? Edge weighting: streamline count, length, or microstructural properties? These choices give rise to a daunting garden of forking paths. In this article, we revise fundamental decisions you must make when planning to build a tractography-based connectome and their impact on its network analysis.</p>

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A thousand ways to tailor your tractography-based connectome

  • 期刊论文

  • 发表日期：

    2025年8月11日

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  • Alessandra Griffa,
  • Francois Rheault,
  • Alessandro Daducci,
  • Andrew Zalesky

摘要

Did you know that there are thousands of ways to build a connectome from diffusion MRI tractography, and the choice of approach can hugely impact the final connectome and results? To name only a few: Tractography type: deterministic or probabilistic? Parcellation resolution: coarse or fine atlas? Edge weighting: streamline count, length, or microstructural properties? These choices give rise to a daunting garden of forking paths. In this article, we revise fundamental decisions you must make when planning to build a tractography-based connectome and their impact on its network analysis.