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<p>Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor characterized by spindle cells with myofibroblastic differentiation, accompanying chronic inflammatory cells, and the hallmark genetic signature of mainly <i>ALK</i> or <i>ROS1</i> rearrangements. Here, we report a lung IMT in a 45-year-old female demonstrating a unique meningothelial-like pattern, equivocal ALK expression (negative for clone 5A4 and positive for clone ALK1), negative <i>ALK</i> rearrangement by FISH, and the presence of the <i>TPM3::ALK</i> fusion. To our knowledge, this is the first reported case of lung IMT displaying meningothelial-like whorls, with a particular focus on differential diagnosis.</p>

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Meningioma-like inflammatory myofibroblastic tumor of the lung with TPM3::ALK fusion

  • 期刊论文

  • 发表日期：

    2026年2月18日

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  • Ali Eren Akın,
  • Ceren Damla Durmaz,
  • Ayşe Nur Yılmaz,
  • Omer Cagri Akcin,
  • Olcay Kurtulan,
  • Sevgen Onder,
  • Kemal Kosemehmetoglu

摘要

Inflammatory myofibroblastic tumor (IMT) is a rare mesenchymal tumor characterized by spindle cells with myofibroblastic differentiation, accompanying chronic inflammatory cells, and the hallmark genetic signature of mainly ALK or ROS1 rearrangements. Here, we report a lung IMT in a 45-year-old female demonstrating a unique meningothelial-like pattern, equivocal ALK expression (negative for clone 5A4 and positive for clone ALK1), negative ALK rearrangement by FISH, and the presence of the TPM3::ALK fusion. To our knowledge, this is the first reported case of lung IMT displaying meningothelial-like whorls, with a particular focus on differential diagnosis.