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<p>Primary laryngeal lymphoma is a rare diagnosis, accounting for less than 1% of all laryngeal tumors. Approximately 100 cases have been reported in the English-language literature. A variety of lymphoma classifications have been described, including diffuse large B-cell lymphoma, NK/T-cell lymphoma, Burkitt lymphoma, lymphoplasmacytic lymphoma, mucosa-associated lymphoid tissue (MALT) lymphoma, mantle cell lymphoma, marginal zone lymphoma, and peripheral T-cell lymphoma. To our knowledge, follicular lymphoma involving the larynx has been rarely reported. We report a case of a 74-year-old woman who presented with a 1-year history of hoarseness refractory to semi-occluded vocal tract (SOVT) therapy and was diagnosed with follicular lymphoma involving the false vocal fold. At presentation, the patient felt well and did not have any B symptoms. Initial computed tomography (CT) scan of the neck did not show any lesions, but a subsequent videolaryngostroboscopy revealed a small lesion in the false vocal folds. The lesion was surgically excised, and histological evaluation revealed features consistent with a diagnosis of follicular lymphoma. Herein, we present a rare case of primary follicular lymphoma of the larynx and describe its histological and immunophenotypic characteristics. Furthermore, we conducted an extensive review of the English-language literature and discuss comparable published cases.</p>

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Unusual case of follicular lymphoma of vocal cord

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月23日

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  • Griffin H. Willman,
  • Zohre Sadeghian,
  • Jyotsna Kochiyil,
  • Chieh Lin Fu,
  • Samuel Trosman,
  • Gulrukh Botiralieva,
  • Natalya Pak,
  • Yaroslav N. Chernov,
  • Shukhrat A. Abdukhalikov,
  • Amir Behdad,
  • Kirill A. Lyapichev

摘要

Primary laryngeal lymphoma is a rare diagnosis, accounting for less than 1% of all laryngeal tumors. Approximately 100 cases have been reported in the English-language literature. A variety of lymphoma classifications have been described, including diffuse large B-cell lymphoma, NK/T-cell lymphoma, Burkitt lymphoma, lymphoplasmacytic lymphoma, mucosa-associated lymphoid tissue (MALT) lymphoma, mantle cell lymphoma, marginal zone lymphoma, and peripheral T-cell lymphoma. To our knowledge, follicular lymphoma involving the larynx has been rarely reported. We report a case of a 74-year-old woman who presented with a 1-year history of hoarseness refractory to semi-occluded vocal tract (SOVT) therapy and was diagnosed with follicular lymphoma involving the false vocal fold. At presentation, the patient felt well and did not have any B symptoms. Initial computed tomography (CT) scan of the neck did not show any lesions, but a subsequent videolaryngostroboscopy revealed a small lesion in the false vocal folds. The lesion was surgically excised, and histological evaluation revealed features consistent with a diagnosis of follicular lymphoma. Herein, we present a rare case of primary follicular lymphoma of the larynx and describe its histological and immunophenotypic characteristics. Furthermore, we conducted an extensive review of the English-language literature and discuss comparable published cases.