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<p>Epithelioid hemangioma (EH) arising from the liver is extremely rare, and its cellular variant can easily lead to diagnostic difficulties. Here, we report a cellular EH of the liver in a 63-year-old man. Microscopically, the lesion was multinodular. Approximately 95% of areas displayed solid and sheet-like growth. It mainly consisted of proliferative epithelioid cells with eosinophilic cytoplasm containing intracytoplasmic vacuoles, admixed with a few eosinophils. Tumor cells were immunoreactive for FOS, CD31, ERG, and CD34, but negative for FOSB, CAMTA1, and TFE-3. Fluorescence in situ hybridization identified <i>FOS</i> gene rearrangement, while <i>FOSB</i> rearrangement, <i>CAMTA1</i> rearrangement, and <i>WWTR1::CAMTA1</i> gene fusion were not detected. Furthermore, next-generation sequencing and Sanger sequencing demonstrated a <i>FOS::BCAR3</i> fusion. To the best of our knowledge, this is the first reported case of cellular EH involving the liver and featuring a novel <i>FOS::BCAR3</i> fusion, thereby broadening the spectrum of clinicopathological and genetic characteristics in this entity.</p>

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A cellular epithelioid hemangioma of the liver harboring a novel FOS::BCAR3 fusion gene

  • 期刊论文

  • 发表日期：

    2025年11月18日

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  • Yang Lu,
  • Xianzhen Cui,
  • Xin He,
  • Min Chen,
  • Hongying Zhang

摘要

Epithelioid hemangioma (EH) arising from the liver is extremely rare, and its cellular variant can easily lead to diagnostic difficulties. Here, we report a cellular EH of the liver in a 63-year-old man. Microscopically, the lesion was multinodular. Approximately 95% of areas displayed solid and sheet-like growth. It mainly consisted of proliferative epithelioid cells with eosinophilic cytoplasm containing intracytoplasmic vacuoles, admixed with a few eosinophils. Tumor cells were immunoreactive for FOS, CD31, ERG, and CD34, but negative for FOSB, CAMTA1, and TFE-3. Fluorescence in situ hybridization identified FOS gene rearrangement, while FOSB rearrangement, CAMTA1 rearrangement, and WWTR1::CAMTA1 gene fusion were not detected. Furthermore, next-generation sequencing and Sanger sequencing demonstrated a FOS::BCAR3 fusion. To the best of our knowledge, this is the first reported case of cellular EH involving the liver and featuring a novel FOS::BCAR3 fusion, thereby broadening the spectrum of clinicopathological and genetic characteristics in this entity.