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<p>Superficial CD34-positive fibroblastic tumor (SCD34FT) and <i>PRDM10</i>-rearranged soft tissue tumor are mesenchymal neoplasms of intermediate malignancy increasingly recognized as the same entity. They typically arise in superficial soft tissues and behave indolently, with a low risk of local recurrence and rare regional metastasis. We describe a SCD34FT in a 48-year-old man with a right triceps mass that underwent neoadjuvant radiation and resection. Within a year, he developed metastasis to the right ninth rib that slowly grew over 6 years. The tumors showed pleomorphic epithelioid and spindled cells in myxoid stroma, prominent nucleoli, scattered bizarre nuclei with smudgy chromatin, in keeping with SCD34FT. Molecular analysis identified a <i>CITED2</i>::<i>PRDM10</i> fusion. Following radiation and resection of the metastasis, the patient remained disease-free at 1 year. This case provides another example of SCD34FT that developed locoregional metastasis to the literature and supports its known biologic behavior as an indolent but rarely metastasizing neoplasm.</p>

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Superficial CD34-positive fibroblastic tumor with locoregional metastasis: a case report

  • 期刊论文

  • 发表日期：

    2025年10月20日

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  • Sintawat Wangsiricharoen,
  • Wendong Yu

摘要

Superficial CD34-positive fibroblastic tumor (SCD34FT) and PRDM10-rearranged soft tissue tumor are mesenchymal neoplasms of intermediate malignancy increasingly recognized as the same entity. They typically arise in superficial soft tissues and behave indolently, with a low risk of local recurrence and rare regional metastasis. We describe a SCD34FT in a 48-year-old man with a right triceps mass that underwent neoadjuvant radiation and resection. Within a year, he developed metastasis to the right ninth rib that slowly grew over 6 years. The tumors showed pleomorphic epithelioid and spindled cells in myxoid stroma, prominent nucleoli, scattered bizarre nuclei with smudgy chromatin, in keeping with SCD34FT. Molecular analysis identified a CITED2::PRDM10 fusion. Following radiation and resection of the metastasis, the patient remained disease-free at 1 year. This case provides another example of SCD34FT that developed locoregional metastasis to the literature and supports its known biologic behavior as an indolent but rarely metastasizing neoplasm.