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<p>Diffuse hemispheric glioma, H3 G34-mutant, is a rare, recently categorized, high-grade, infiltrative glioma. It usually occurs in the cerebral hemispheres of adolescents and young adults. Mutations in the <i>H3-3A</i> gene play a key oncogenic role in the pathogenesis of this entity, with missense mutations caused by amino acid substitutions at p.G35 (G34) position being the most common. The tumor has a broad histological spectrum, a distinct immunoprofile, and a dismal prognosis. Only a few studies have provided a detailed histopathological analysis of this tumor, and to the best of our knowledge, no study has been published on this tumor within the Pakistani population. The aim of this study is to provide an account of our experience with this tumor within the Pakistani population. Here, we provide a retrospective analysis of 13 cases diagnosed at our hospital, highlighting the extremely varied morphology we encountered, along with their complete immunohistochemical workup.</p>

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Diffuse hemispheric glioma, H3 G34-mutant, a single centre experience and histopathological analysis

  • 期刊论文

  • 发表日期：

    2025年10月8日

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  • Faizan Amer,
  • Usman Hassan,
  • Sajid Mushtaq,
  • Asif Loya,
  • Mudassar Hussain,
  • Hina Maqbool

摘要

Diffuse hemispheric glioma, H3 G34-mutant, is a rare, recently categorized, high-grade, infiltrative glioma. It usually occurs in the cerebral hemispheres of adolescents and young adults. Mutations in the H3-3A gene play a key oncogenic role in the pathogenesis of this entity, with missense mutations caused by amino acid substitutions at p.G35 (G34) position being the most common. The tumor has a broad histological spectrum, a distinct immunoprofile, and a dismal prognosis. Only a few studies have provided a detailed histopathological analysis of this tumor, and to the best of our knowledge, no study has been published on this tumor within the Pakistani population. The aim of this study is to provide an account of our experience with this tumor within the Pakistani population. Here, we provide a retrospective analysis of 13 cases diagnosed at our hospital, highlighting the extremely varied morphology we encountered, along with their complete immunohistochemical workup.