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<p>Benign lymphoepithelial tumors of salivary glands had been restricted to sebaceous and non-sebaceous (NSLA) lymphadenomas. However, salivary neoplasms recapitulating carcinoma showing thymus-like elements (CASTLE) have been the subject of recent case reports. We reviewed clinicopathological, immunohistochemical, and molecular findings in 20 salivary gland tumors with thymus-like phenotype (18 histologically benign and two with malignant component). Original diagnoses were NSLA (<i>n</i> = 11) and unclassified thymus-like lymphoepithelial neoplasms (<i>n</i> = 9). Patients were 13 males and 7 females aged 28 to 83&#xa0;years (median, 61). All tumors originated in the parotid with a median tumor size of 2.7&#xa0;cm. A cystic component was noted in eight cases (40%). Histologically, the tumors were composed of large squamoid cells with indistinct cell borders, forming large irregular branching and anastomosing aggregates within lymphoid stroma with Hassall corpuscle-like structures and intraepithelial sprinkling of lymphocytes. All tumors were diffusely&#xa0;positive for p63/p40 and CK5/CK14. CD5 and CD117 were expressed in 13/20 (65%) and 15/19 (79%) cases, respectively. The malignant component in two cases showed lower CD5/CD117 expression. Targeted DNA sequencing revealed pathogenic/likely pathogenic <i>CYLD</i> mutations in 4/7 cases (57%). One case each had a mutation in <i>TAF1</i> + <i>WISP3</i>,<i> DNMT3A</i>, and <i>BCOR</i>. Targeted RNA sequencing revealed a <i>YAP1::MAML2</i> fusion in 1/7 cases. This is the first systematic study addressing the concept of thymus-like phenotype in benign lymphoepithelial salivary gland tumors, showing that the majority of NSLAs (65%) belong to this poorly characterized category. Frequent <i>CYLD</i> mutations in these histologically distinct&#xa0;tumors represent a novel addition to&#xa0;the spectrum of <i>CYLD</i>-mutated salivary neoplasms.</p>

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Thymus-like phenotype in benign lymphoepithelial neoplasms of salivary glands: clinicopathological and molecular characterization and reappraisal of relationship to non-sebaceous lymphadenoma

  • 期刊论文

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  • 发表日期：

    2025年9月6日

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  • Abbas Agaimy,
  • Jan Laco,
  • Christoph Schubart,
  • Robert Stoehr,
  • Lars Tögel,
  • Stephan Ihrler

摘要

Benign lymphoepithelial tumors of salivary glands had been restricted to sebaceous and non-sebaceous (NSLA) lymphadenomas. However, salivary neoplasms recapitulating carcinoma showing thymus-like elements (CASTLE) have been the subject of recent case reports. We reviewed clinicopathological, immunohistochemical, and molecular findings in 20 salivary gland tumors with thymus-like phenotype (18 histologically benign and two with malignant component). Original diagnoses were NSLA (n = 11) and unclassified thymus-like lymphoepithelial neoplasms (n = 9). Patients were 13 males and 7 females aged 28 to 83 years (median, 61). All tumors originated in the parotid with a median tumor size of 2.7 cm. A cystic component was noted in eight cases (40%). Histologically, the tumors were composed of large squamoid cells with indistinct cell borders, forming large irregular branching and anastomosing aggregates within lymphoid stroma with Hassall corpuscle-like structures and intraepithelial sprinkling of lymphocytes. All tumors were diffusely positive for p63/p40 and CK5/CK14. CD5 and CD117 were expressed in 13/20 (65%) and 15/19 (79%) cases, respectively. The malignant component in two cases showed lower CD5/CD117 expression. Targeted DNA sequencing revealed pathogenic/likely pathogenic CYLD mutations in 4/7 cases (57%). One case each had a mutation in TAF1 + WISP3, DNMT3A, and BCOR. Targeted RNA sequencing revealed a YAP1::MAML2 fusion in 1/7 cases. This is the first systematic study addressing the concept of thymus-like phenotype in benign lymphoepithelial salivary gland tumors, showing that the majority of NSLAs (65%) belong to this poorly characterized category. Frequent CYLD mutations in these histologically distinct tumors represent a novel addition to the spectrum of CYLD-mutated salivary neoplasms.