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<p>Plasma cell disorders in the lungs include a broad range of conditions from benign reactive processes to malignant neoplasms. This article provides a comprehensive analysis of these diseases, focusing on their histopathological, immunohistochemical, and diagnostic characteristics. Four case studies illustrate the diagnostic challenges in distinguishing between reactive plasma cell infiltrates and neoplastic conditions. Key diagnostic tools, such as histological analysis and molecular techniques, are discussed to guide clinical evaluation. A systematic approach to diagnosis and management is mandatory for treatment decisions. Understanding the full spectrum of plasma cell abnormalities in the lung enables clinicians and pathologists to achieve accurate diagnoses and improve patient outcomes.</p>

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Pulmonary plasma cell disorders: histopathology, diagnosis, and clinical perspectives

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年8月23日

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  • Federica Pezzuto,
  • Giordano Fiorentù,
  • Gioele Castelli,
  • Simone Zanella,
  • Chiara Giraudo,
  • Marianerica Tinè,
  • Fiorella Calabrese

摘要

Plasma cell disorders in the lungs include a broad range of conditions from benign reactive processes to malignant neoplasms. This article provides a comprehensive analysis of these diseases, focusing on their histopathological, immunohistochemical, and diagnostic characteristics. Four case studies illustrate the diagnostic challenges in distinguishing between reactive plasma cell infiltrates and neoplastic conditions. Key diagnostic tools, such as histological analysis and molecular techniques, are discussed to guide clinical evaluation. A systematic approach to diagnosis and management is mandatory for treatment decisions. Understanding the full spectrum of plasma cell abnormalities in the lung enables clinicians and pathologists to achieve accurate diagnoses and improve patient outcomes.