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<p>The two cases, we had presented here, were extremely rare instances of the <i>EWSR1::BEND2</i> fusion sarcomas in bone. The first case was a 12-year-old female with a 50 × 25-mm lytic tumor in metatarsal bone. Histopathologic examination revealed a widespread cellular, fascicular forming, spindled cell component along with a focal round cell component. CD99 was diffuse membranous positive while cytokeratin and EMA were focal positive. The second case was a 62-year-old female with a pathological fracture in femur. On MRI examination, a heterogeneous tumor measuring 96 × 54&#xa0;mm was detected in the femur, extending into the soft tissue. Histopathologic examination revealed a high-grade lesion consisting of round cells. CD56, CD99, and cytokeratin were focal positive. <i>EWSR1::BEND2</i> fusion has previously been reported in a subtype of astroblastoma and other rare entities that we discuss in this work.</p>

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EWSR1::BEND2 fusion sarcoma in bone: a report of two rare cases

  • 期刊论文

  • 发表日期：

    2025年3月5日

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  • Sırma Çetin,
  • Gökçen Ünverengil,
  • İsmail Yılmaz,
  • Nilsen Erdoğan,
  • Ayça Erşen Danyeli,
  • Ahmet Salduz,
  • Bilge Bilgiç

摘要

The two cases, we had presented here, were extremely rare instances of the EWSR1::BEND2 fusion sarcomas in bone. The first case was a 12-year-old female with a 50 × 25-mm lytic tumor in metatarsal bone. Histopathologic examination revealed a widespread cellular, fascicular forming, spindled cell component along with a focal round cell component. CD99 was diffuse membranous positive while cytokeratin and EMA were focal positive. The second case was a 62-year-old female with a pathological fracture in femur. On MRI examination, a heterogeneous tumor measuring 96 × 54 mm was detected in the femur, extending into the soft tissue. Histopathologic examination revealed a high-grade lesion consisting of round cells. CD56, CD99, and cytokeratin were focal positive. EWSR1::BEND2 fusion has previously been reported in a subtype of astroblastoma and other rare entities that we discuss in this work.