Scholarlink

<p>We present the clinicopathologic and molecular characteristics of a rare sinonasal sarcoma with undifferentiated round cell and spindle morphology, defined by the <i>EWSR1::POU2AF3</i> fusion. A 62-year-old male presented with nasal congestion. A polypoid lesion excised from the sinonasal cavity was initially diagnosed as 'glomangiopericytoma' at an external center, but recurred and was referred to our clinic four years later. Histopathological evaluation of primary and recurrent tumors showed pleomorphic spindle and round cell morphology with prominent nucleoli and thin-walled hemangiopericytomatous vessels. CD99 (MIC2) and CD117 (CKIT) were diffuse positivite while ß-catenin showed cytoplasmic/membranous expression. Pancytokeratin and EMA were focally positive. NKX2.2, DUX4, ETV4, BCOR, CCNB3, SS18-SSX, STAT6, CD34, and others were all negative. Next generation sequencing confirmed <i>EWSR1::POU2AF3</i> fusion. This case exemplifies a rare, aggressive sinonasal sarcoma with <i>EWSR1::POU2AF3</i> fusion, emphasizing its distinct morphology and challenging behaviour.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Sinonasal EWSR1::POU2AF3 sarcoma: a case report and literature review

  • 期刊论文

  • 发表日期：

    2025年2月21日

查看全文
  • Sırma Çetin,
  • İsmail Yılmaz,
  • Doğu Vurallı Bakkaloğlu,
  • Mehmet Çelik,
  • Bilge Bilgiç,
  • Yasemin Özlük

摘要

We present the clinicopathologic and molecular characteristics of a rare sinonasal sarcoma with undifferentiated round cell and spindle morphology, defined by the EWSR1::POU2AF3 fusion. A 62-year-old male presented with nasal congestion. A polypoid lesion excised from the sinonasal cavity was initially diagnosed as 'glomangiopericytoma' at an external center, but recurred and was referred to our clinic four years later. Histopathological evaluation of primary and recurrent tumors showed pleomorphic spindle and round cell morphology with prominent nucleoli and thin-walled hemangiopericytomatous vessels. CD99 (MIC2) and CD117 (CKIT) were diffuse positivite while ß-catenin showed cytoplasmic/membranous expression. Pancytokeratin and EMA were focally positive. NKX2.2, DUX4, ETV4, BCOR, CCNB3, SS18-SSX, STAT6, CD34, and others were all negative. Next generation sequencing confirmed EWSR1::POU2AF3 fusion. This case exemplifies a rare, aggressive sinonasal sarcoma with EWSR1::POU2AF3 fusion, emphasizing its distinct morphology and challenging behaviour.