Main conclusion <p>This review summarizes manganese hyperaccumulators and plant mechanisms for tolerating excess Mn to advance phytoremediation.</p> Abstract <p>Manganese (Mn) is an essential micronutrient for plant growth and development, extensively involved in various physiological processes, but becomes phytotoxic when in excess. In recent years, amid rapid industrialization and urbanization, environmental Mn pollution has intensified, posing a significant threat to ecosystems and human health. Among various remediation technologies, phytoremediation has garnered significant attention for its environmental friendliness and cost-effectiveness. Globally, numerous Mn hyperaccumulators have been identified, including <i>Phytolacca americana</i> L., <i>Celosia argentea</i> L., and <i>Persicaria perfoliata</i> (L.) H. Gross. These plants not only thrive in high-Mn environments but also exhibit strong Mn accumulation and tolerance, making them ideal candidates for the remediation of Mn pollution. Compared to existing reviews, this review provides a systematic compilation of Mn hyperaccumulator resources reported in both domestic and international studies. It is the first to offer a comprehensive synthesis of multiple mechanisms underlying tolerance to Mn excess, encompassing compartmentalization, antioxidant effects, chelation, restriction of uptake and efflux, and plant–microbe interactions. Particular emphasis is placed on integrating and applying omics research in this field. This review aims to provide a theoretical reference for further elucidating the mechanisms of plant tolerance to excess Mn, exploring plant resources with high Mn tolerance, and promoting the practical application of phytoremediation technology.</p>